FAT METABOLISM AND EXPERIMENTAL ATHEROSCLEROSIS

脂肪代谢和实验性动脉粥样硬化

• 批准号: 3334392
• 负责人: DONALD B. ZILVERSMIT
• 金额: $ 28.74万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1991-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3334392
• 关键词: aorta; apolipoproteins; artery; atherosclerosis; blood lipoprotein metabolism; cholesterol esters; cortisone; detergents; disease /disorder model; fibroblasts; hypertriglyceridemia; lipid metabolism; lipid transport; lipogenesis inhibitor; low density lipoprotein; molecular pathology; molecular size; pinocytosis; radionuclide double label; steroid metabolism; tissue /cell culture; triglycerides; very low density lipoprotein

Research will continue on the role of plasma triglycerides in atherogenesis. Several models will be studied: Alloxan diabetic rabbit, adrenal corticoid administration, detergent injections. The role of lipoprotein particle size and composition in the rate of liquid uptake and in vivo hydrolysis of fatty acid esters will be examined. We also expect to study a potential role of plasma lipid transfer activity in atherogenesis. Lipid transfer activity in rabbits is high and increases during hypercholesterolemia, whereas the rat has little or no such activity in plasma. Methods for altering the composition of plasma lipoproteins will be developed and in vivo clearance of modified lipoproteins will be compared to the original lipoprotein clearance.

将继续研究血浆甘油三酯在