FAT METABOLISM AND EXPERIMENTAL ATHEROSCLEROSIS

脂肪代谢和实验性动脉粥样硬化

• 批准号: 3334395
• 负责人: DONALD B. ZILVERSMIT
• 金额: $ 31.39万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1991-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3334395
• 关键词: aorta; apolipoproteins; artery; atherosclerosis; blood lipoprotein metabolism; cholesterol esters; cortisone; detergents; disease /disorder model; drug related diabetes mellitus; fibroblasts; hypertriglyceridemia; laboratory rabbit; laboratory rat; lipid metabolism; lipid transport; lipogenesis inhibitor; low density lipoprotein; molecular pathology; molecular size; pinocytosis; radionuclide double label; steroid metabolism; tissue /cell culture; transport proteins; triglycerides; tritium; very low density lipoprotein

Research will continue on the role of plasma triglycerides in atherogenesis. Several models will be studied: Alloxan diabetic rabbit, adrenal corticoid administration, detergent injections. The role of lipoprotein particle size and composition in the rate of liquid uptake and in vivo hydrolysis of fatty acid esters will be examined. We also expect to study a potential role of plasma lipid transfer activity in atherogenesis. Lipid transfer activity in rabbits is high and increases during hypercholesterolemia, whereas the rat has little or no such activity in plasma. Methods for altering the composition of plasma lipoproteins will be developed and in vivo clearance of modified lipoproteins will be compared to the original lipoprotein clearance.

研究将继续对血浆甘油三酯的作用， 动脉粥样硬化 将研究几种模型：四氧嘧啶糖尿病兔， 肾上腺皮质激素注射清洁剂注射 的作用 脂蛋白颗粒大小和组成的液体摄取率， 将检查脂肪酸酯的体内水解。 我们也期待 研究血浆脂质转运活性在 动脉粥样硬化 家兔的脂质转移活性高， 在高胆固醇血症期间，而大鼠几乎没有或没有这种活动， 在血浆中。 改变血浆脂蛋白组成的方法 将开发和在体内清除修饰的脂蛋白将是 与最初的脂蛋白清除率相比。