GENETIC EPIDEMIOLOGY OF HUMAN FETAL GROWTH

人类胎儿生长的遗传流行病学

• 批准号: 3323697
• 负责人: RICHARD H WARD
• 金额: $ 15.06万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3323697
• 关键词: developmental genetics; disease /disorder proneness /risk; embryo /fetus; embryo /fetus death; embryology; epidemiology; histogenesis; human ecology; human fetus tissue; infant mortality; medical records; online computer; pregnancy disorder; premature infant human

Fetal growth represents a fundamental biological parameter for all mammalian species. In the human species, the distribution of fetal growth assumes an added dimension of great public health importance because it defines the frequency of babies most likely to die during infancy - the intra uterine growth retarded (IUGR) baby. Despite the importance of fetal growth as a primary determinant of health during infancy and early childhood, we known very little about the intrinsic factors that modify the distribution of fetal growth in populations. In particular, we lack a clear understanding of how genetic factors influence fetal growth in Man, and the extent to which maternal and environmental variables constrain the genetic growth potential of the fetus. This study aims to carry out the first comprehensive investigation of the interactions between genetic, maternal and environmental factors which influence the distribution of fetal growth in an entire, defined, U.S. population -the state of Utah. First, a data base of linked Utah birth records will be created for the approximately 318,814 live and still births born between 1940- 55 (parental cohort) and the approximately 581,447 births born between 1970-85. Record linking within each cohort will form parental sibships and offspring sibships, while record linking between cohorts will form nuclear families and cousin sets. We anticipate forming about 100,000 nuclear families with birth records (of which nearly 30,000 will have completed reproduction) and 200,000 cousin sets. Second, this data base will be analyzed to: a) evaluate the effect of various environmental and demographic concomitants on fetal growth. b) determine the impact of fetal growth constraints on mortality. c) identify the relative contribution of genetic, maternal and environmental factors on fetal growth using path analysis and segregation analysis. d) test hypotheses concerning the mechanism of maternal influences on fetal growth, and evaluate the magnitude of natural selection due to fetal growth.

胎儿生长是一个基本的生物学参数， 所有哺乳动物物种。 在人类中， 胎儿的发育是公共健康的一个重要方面 重要性，因为它定义了婴儿的频率最有可能 胎儿宫内发育迟缓（IUGR） 宝贝 尽管胎儿生长作为一个主要的 在婴儿期和幼儿期的健康决定因素， 我们对改变这种现象的内在因素知之甚少。 胎儿生长在人群中的分布。 特别是，我们缺乏 清楚地了解遗传因素如何影响胎儿 人的成长，以及在多大程度上， 环境变量限制了遗传生长潜力， 胎儿 本研究旨在开展第一次全面的 研究遗传、母体和 影响胎儿分布的环境因素 整个美国人口的增长--犹他州。 首先，将建立一个链接犹他州出生记录的数据库， 1940年至2000年期间出生活产和死胎约318 814例， 55（父母队列）和大约581，447出生 在1970-85年间。 将形成每个队列内的记录链接 父母兄弟姐妹和后代兄弟姐妹，而记录链接 会形成核心家庭和表亲 我们 预计将有大约10万个核心家庭 记录（其中将近30 000份将完成复制） 和20万个表亲 第二，将对该数据库进行分析，以便： （a）评估各种环境和人口影响 伴随胎儿生长。 B）确定胎儿生长限制对死亡率的影响。 c）确定遗传、母体和 环境因素对胎儿生长的通径分析 分离分析 （d）检验关于产妇死亡机制的假设 对胎儿生长的影响，并评估自然生长的程度。 由于胎儿生长的选择。