METABOLISM IN THE NONHUMAN PRIMATE AND OVINE FETUS

非人灵长类动物和绵羊胎儿的新陈代谢

• 批准号: 3322805
• 负责人: Lynne L. Levitsky
• 金额: $ 26.45万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3322805
• 关键词: biological models; carbohydrate biosynthesis; catecholamines; catheterization; embryo /fetus; gluconeogenesis; glycogenolysis; high performance liquid chromatography; homeostasis; hormone regulation /control mechanism; kidney metabolism; liver metabolism; metabolism; placental transfer; prenatal stress; radioimmunoassay; radiotracer; tritium; ultrasound blood flow measurement

The study continues investigations into the nature of energy metabolism in the fetus. A chronic fetal lamb preparation and a chronic nonhuman primate model, the fetal baboon, are being used to extend previous studies of quantitative energy metabolism. Substrate uptake and production by the fetal animals is being evaluated by utilizing appropriately placed arterial and venous catheters for sampling arteriovenous metabolic differences, radioactive precursor tracer techniques, and measures of fetal blood flow and specific organ blood flows. We plan to study the capacity of the fetus to control gluconeogenesis, glycogenesis, and glycogenolysis in the face of a hostile maternal metabolic milieu, focusing particularly on endogenous hormonal or substrate mediated control mechanisms. In addition, pharmacologic probes of hormonal control mechanisms will be employed during steady state conditions in the pregnant animal. These studies are immediately relevant to the clinical problems of the infant of the diabetic mother, who may be exposed to acute hypoglycemia, or acute and chronic hyperglycemia, and to the infant of the calorically deprived, undernourished mother.

这项研究继续调查能量代谢的性质， 胎儿 慢性胎羊制备物和慢性非人灵长类动物 模型，胎儿狒狒，正在被用来扩展以前的研究， 定量能量代谢 底物的吸收和生产 通过使用适当放置的动脉 以及用于对动静脉代谢差异进行采样的静脉导管， 放射性前体示踪技术和胎儿血流测量 和特定器官的血流 我们计划研究胎儿的能力 在面对糖尿病时控制糖原生成、糖原生成和糖原分解， 一个敌对的母体代谢环境，特别关注内源性 激素或底物介导的控制机制。 此外，本发明还提供了一种方法， 激素控制机制的药理学探针将在 妊娠动物的稳态条件。 这些研究 与糖尿病婴儿的临床问题直接相关， 母亲，可能暴露于急性低血糖，或急性和慢性低血糖 高血糖症，和婴儿的热量剥夺， 营养不良的母亲