Bioplatform Grant Renewal: Next Generation Biophotonics

生物平台拨款续签：下一代生物光子学

• 批准号: EP/G061688/1
• 负责人: Kishan Dholakia
• 金额: $ 142.27万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG061688%2F1
• 关键词: Bioplatform; Grant; Renewal; Next; Generation

Light is quite astounding: our understanding of light and its applications has grown immensely, particularly following the invention of the laser nearly fifty years ago. Major strides are now being made to use light in modern biomedical applications and healthcare. This area may be termed Biophotonics and encompasses all interactions of light with biological specimens. The aim of this grant is to capitalise upon the major internationally recognised success of the St Andrews team in this area. Our previous Platform grant allowed us to establish major new strands of research in this topic area, that have reached international status. This includes the areas of targeted delivery with light of biological material (photoporation), Raman (taking an optical fingerprint of cells for diagnosis of cell abnormality) and photodynamic therapy (using light for cancer treatment) amongst others. The aim of our new grant is to sustain and enhance our activities that ensure our cohesive working practices, as well as pump-priming key feasibility studies in the areas of single molecules, cell biology and clinical applications. The emphasis is to move towards real world applications and runs in parallel with the advent of a new Medical School at St Andrews, as well as several current and upcoming appointments in Biophotonics. In tandem, we are very keen to retain, develop and promote the careers of very promising young PDRAs in this exciting field, as well as gain international visibility by fostering new projects through visits and pump-prime studies. Thus the large bulk of funding will cover salaries for young people to carry out the feasibility studies. The success of the new grant will be measured through the career progression of these people, the generation of new responsive mode grants, and dissemination through journal and conference papers with joint authorship between the Schools at St Andrews but also with international colleagues as appropriate.

光是相当惊人的：我们对光及其应用的理解有了极大的增长，特别是在近50年前激光发明之后。光在现代生物医学应用和医疗保健方面取得了重大进展。这一领域可称为生物光子学，包括光与生物标本的所有相互作用。这项资助的目的是利用圣安德鲁斯大学团队在这一领域取得的国际公认的重大成功。我们以前的平台资助使我们能够在这一主题领域建立重要的新研究分支，这些研究分支已达到国际地位。这包括生物材料的靶向递送（光穿孔）、拉曼（提取细胞的光学指纹以诊断细胞异常）和光动力治疗（利用光治疗癌症）等领域。我们新拨款的目的是维持和加强我们的活动，以确保我们的凝聚力工作实践，以及在单分子、细胞生物学和临床应用领域开展关键的可行性研究。重点是走向现实世界的应用，并与圣安德鲁斯新医学院的到来并行，以及生物光子学的几个当前和即将到来的任命。与此同时，我们非常渴望在这个令人兴奋的领域留住、发展和促进非常有前途的年轻PDRAs的职业生涯，并通过访问和重点研究培养新项目来获得国际知名度。因此，大部分资金将用于支付青年进行可行性研究的薪金。新资助的成功将通过这些人的职业发展、新的响应模式资助的产生、以及通过圣安德鲁斯学院联合撰写的期刊和会议论文的传播来衡量，也可以酌情与国际同事合作。

项目成果

The application of optical coherence tomography to image subsurface tissue structure of Antarctic krill Euphausia superba.

• DOI: 10.1371/journal.pone.0110367
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Bellini N;Cox MJ;Harper DJ;Stott SR;Ashok PC;Dholakia K;Kawaguchi S;King R;Horton T;Brown CT
• 通讯作者: Brown CT