Resonant and shaped photonics for understanding the physical and biomedical world

用于理解物理和生物医学世界的谐振和成形光子学

• 批准号: EP/P030017/1
• 负责人: Kishan Dholakia
• 金额: $ 640.09万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP030017%2F1
• 关键词: Resonant; shaped; photonics; understanding; physical

Light has been used for centuries to image the world around us, and continues to provide profound insights across physics, chemistry, biology, materials science and medicine. However, what are the limits of light as a measurement tool? For example, we can use light to image single bacteria, but can we also use light to trap a single bacterium, identify the bacterial strain and assess its susceptibility to antibiotics? How can we image over multiple length scales, from single cells to multiple cellular tissue, in order to comprehensively map all the neuronal connections in the brain? Can we use a combination of resonance with the wave nature and momentum of light to measure the forces associated with the natural and stimulated motion of a single neuronal cell, or even the extremely small forces associated with phenomena at the classical-quantum interface? This proposal aims to answer these questions by exploring new and innovative ways in which we can use light to measure the natural world. This research builds on our recent advances in photonics - the science of generating, controlling and detecting light - and in particular will exploit resonant structures and shaped light. These provide us with tools for controlling the interaction of light and matter with exquisite sensitivity and accuracy. We will run three research strands in parallel and by combining their outputs, we aim to address major Global Challenges in antimicrobial resistance, neurodegenerative disease, multimodal functional imaging and next generation force, torque and microrheology.Our work is supported by a suite of UK and International project partners (both academic and industry) who are enthused to work with us and have committed over £0.5M in kind to the programme.

几个世纪以来，光一直被用来描绘我们周围的世界，并继续为物理、化学、生物学、材料科学和医学提供深刻的见解。然而，光作为测量工具的局限性是什么？例如，我们可以用光来成像单个细菌，但我们是否也可以用光来捕获单个细菌，识别细菌菌株并评估其对抗生素的敏感性？我们如何在多个长度尺度上成像，从单个细胞到多个细胞组织，以便全面绘制大脑中所有神经元的连接？我们能否结合光的波动性质和动量的共振来测量与单个神经元细胞的自然运动和受刺激运动相关的力，甚至是与经典-量子界面现象相关的极小的力？该提案旨在通过探索新的和创新的方式来回答这些问题，我们可以用光来测量自然世界。这项研究建立在我们最近在光子学（产生、控制和探测光的科学）方面的进展之上，特别是将开发共振结构和形光。这些为我们提供了控制光与物质相互作用的工具，具有极高的灵敏度和准确性。我们将并行运行三个研究链，并通过结合其产出，我们的目标是解决抗生素耐药性、神经退行性疾病、多模态功能成像和下一代力、扭矩和微流变学方面的主要全球挑战。我们的工作得到了一系列英国和国际项目合作伙伴（包括学术界和工业界）的支持，他们热衷于与我们合作，并承诺为该计划提供超过50万英镑的实物资助。

项目成果

Optical binding of two cooled micro-gyroscopes levitated in vacuum

• DOI: 10.1364/optica.5.000910
• 发表时间: 2018-08-20
• 期刊: OPTICA
• 影响因子: 10.4
• 作者: Arita, Yoshihiko;Wright, Ewan M.;Dholakia, Kishan
• 通讯作者: Dholakia, Kishan

All-Optical Assay to Study Biological Neural Networks.

• DOI: 10.3389/fnins.2018.00451
• 发表时间: 2018
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Afshar Saber W;Gasparoli FM;Dirks MG;Gunn-Moore FJ;Antkowiak M
• 通讯作者: Antkowiak M

Cooling the optical-spin driven limit cycle oscillations of a levitated gyroscope

冷却悬浮陀螺仪的光学自旋驱动的极限环振荡

• DOI: 10.1038/s42005-023-01336-4
• 发表时间: 2023
• 期刊: Communications Physics
• 影响因子: 5.5
• 作者: Arita Y

Invited Article: Optical trapping of ultrasmooth gold nanoparticles in liquid and air

• DOI: 10.1063/1.5030404
• 发表时间: 2018-07-01
• 期刊: APL PHOTONICS
• 影响因子: 5.6
• 作者: Arita, Y.;Tkachenko, G.;Dholakia, K.
• 通讯作者: Dholakia, K.