SONOPTICS: EXPLOITING ULTRASOUND AND LASER SCIENCES FOR GENERIC NON-INVASIVE THERAPIES

SONOPTICS：利用超声波和激光科学进行通用非侵入性治疗

• 批准号: EP/D04877X/1
• 负责人: Kishan Dholakia
• 金额: $ 130.41万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD04877X%2F1
• 关键词: SONOPTICS; EXPLOITING; ULTRASOUND; LASER; SCIENCES

The objective of this Basic Technology proposal is to revolutionise the delivery of genes, drugs and therapeutic molecules to single cells and tissue samples. We will use a unique marriage of concepts extracted from ultrasonics and photonics that are intrinsically generic in applicability. This new field will deliver unprecedented accuracy and control for delivery, together with improved efficacy and selectivity, and a much reduced risk of infection. This research will lead to a quantum leap for biologists who are studying the cell's chemical pathways or signals (cellular signal transduction) through to histological/clinical approaches. For example within a population of cells it will be possible to target each cell individually, introducing foreign biological material into any cell. This is central for studies in numerous human diseases. By the use of fibre optic delivery and endoscopes, we envisage that the realisation of this basic technology may allow us to develop a non-invasive surgical technique.

这项基础技术提案的目标是彻底改变基因、药物和治疗分子向单细胞和组织样本的输送。我们将使用从超声波和光子学中提取的概念的独特婚姻，这些概念在适用性上本质上是通用的。这一新领域将提供前所未有的准确性和交付控制，同时提高疗效和选择性，并大大降低感染风险。这项研究将为正在研究细胞的化学途径或信号（细胞信号转导）的生物学家带来一个巨大的飞跃，直到组织学/临床方法。例如，在一群细胞中，可以单独靶向每个细胞，将外来生物材料引入任何细胞。这是许多人类疾病研究的核心。通过使用光纤传输和内窥镜，我们设想实现这一基本技术可能使我们能够开发一种非侵入性手术技术。

项目成果

Optical injection of mammalian cells using a microfluidic platform.

• DOI: 10.1364/boe.1.000527
• 发表时间: 2010-08-09
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Marchington RF;Arita Y;Tsampoula X;Gunn-Moore FJ;Dholakia K
• 通讯作者: Dholakia K

Transient transfection of mammalian cells using a violet diode laser.

• DOI: 10.1117/1.3430730
• 发表时间: 2010-07
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: M. L. Torres-Mapa;Liselotte Angus;M. Ploschner;K. Dholakia;F. Gunn-Moore