PREVENTION OF HIGH BLOOD PRESSURE IN CHILDREN

这项纵向研究将继续测量血压，身高， 体重，皮褶厚度和身体周长的1,082名儿童，现在一次 每年。 研究样本是一个稳定的儿童人口选择 在10,500名儿童中，98%以上都是一年级，二年级， 1978年春天，明尼阿波利斯公立学校系统的3名学生。 所有 非黑人或白色儿童，所有儿童从顶部和底部的5%， 收缩压（BP）分布和1/2黑色样本 儿童和1/9的白色儿童的样本从其余的BP 在1978年至1980年的春季和秋季， 以及1982年至1985年的血压和体型测量。 1,000+儿童 1978年，也曾在家中接受过广泛的心理治疗， 病史、饮食史、人口统计学数据和隔夜尿 收集Na+、K+和肌酐。 此外，本发明还提供了一种方法， 血压、身高、体重、病史、心理数据和 生活事件的数据已经收集了父母一起广泛的 脂肪分布的测量和进一步的医疗和饮食史， 1985. 1981年，没有进行筛查，但获得了同意， 在学校的剩余几年及以后继续进行筛查。 在 1982年，对395例小儿红细胞22 Na ~+外排率进行了测定 617父母 这将在1985年重复，同时采取措施， 钠-锂反向转运和钠-钾共转运。 在研究过程中，基线数据和实验室和A型 分类数据将用于开发血液的预测方程， 在青春期后期和年轻时， 成年 这将包括“跟踪”索引的推导， 这个指数的预测值。 这些可能提供病因学线索， 原发性高血压，并允许深入研究其他因素， 儿童被发现处于最高风险。 从这样的预测 通过研究，将有可能制定初级预防战略， 和更详细的检查病因的基本 高血压

This longitudinal study will continue measuring blood pressure, height, weight, skinfold thickness and body girths of 1,082 children, now once annually. The study sample is a stable population of children selected from more than 98% of 10,500 children being all children in grades 1, 2, and 3 of the Minneapolis Public School System in the spring of 1978. All non-black or white children, all children from the top and bottom 5% of the systolic blood pressure (BP) distribution, and a 1/2 sample of black children and a 1/9 sample of white children from the rest of the BP distribution were followed 2x per year in spring and fall of 1978 to 1980 and 1982 to 1985 for BP and body size measurements. These 1,000+ children have also been visited at home in 1978 when extensive psychological, medical history, dietary history, demographic data, and overnight urine collection for Na+, K+ and creatinine have been gathered. In addition, blood pressure, height, weight, medical history, psychological data and Life Event data have been gathered on the parents together with extensive measurements of fat distribution and further medical and dietary history in 1985. In 1981 no screening was performed but consent was obtained to continue screening through the remaining years of school and beyond. In 1982, 22Na+ red blood cell (rbc) efflux rate was measured in 395 children and 617 parents. This will be repeated in 1985 together with measures of sodium lithium countertransport and sodium potassium cotransport. During the course of the study, baseline data and laboratory and Type A classification data will be used to develop predictive equations for blood pressure levels in the highest percentiles in late adolescence and young adulthood. This will include derivation of an index of "tracking" and the predictive value of this index. These may provide etiological clues to essential hypertension and allow indepth study of other factors among children to be found at highest risk. From such proposed predictive studies it will be possible to develop strategies for primary prevention and more detailed examination of etiological factors of essential hypertension.