Bridging the Gaps: Nano-Info-Bio

弥合差距：纳米信息生物

• 批准号: EP/H000291/1
• 负责人: Martyn Amos
• 金额: $ 36.84万
• 依托单位: Manchester Metropolitan University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH000291%2F1
• 关键词: Bridging; Gaps; Nano; Info; Bio

Many of the complex challenges facing 21st century society will require solutions that transcend disciplinary boundaries. The convergence of nanotechnology, information technologies and biotechnology is widely predicted to lie at the heart of the next technological revolution. Nano-info-bio science and technology has the potential to fundamentally transform healthcare, agriculture, energy, security, environmental science and many other areas of pressing concern. MMU is ideally placed to take advantage of and contribute to these developments. We have a strong research presence in each of nanoscience, informatics and biosciences. However, while the relevant groups carry out internationally-renowned work in their own domains, there has been, so far, little cross-fertilization between certain communities.Our programme will stimulate activities at the interfaces of nano-info-bio, initially drawing on members of the Dalton Research Institute (DRI) and the Institute for Biomedical Research into Human Movement and Health (IRM). The IRM has recently relocated to the main University campus, and the proposed programme will provide an ideal vehicle for creating entirely new institutional partnerships. We therefore seek to build (and strengthen) links between computational scientists/mathematicians/engineers and their counterparts in the natural/life/health sciences. We propose a grass-roots programme of fine-grained project support that will maximise opportunity for involvement and encourage serendipitous contact between different disciplines. By operating within a challenge-driven framework, we will drive the programme to produce tangible outcomes and lay the foundations for long-term sustainability.

世纪社会面临的许多复杂挑战将需要超越学科界限的解决方案。人们普遍预测，纳米技术、信息技术和生物技术的融合将成为下一次技术革命的核心。纳米信息生物科学和技术有可能从根本上改变医疗保健，农业，能源，安全，环境科学和许多其他迫切关注的领域。MMU是利用这些发展并为之做出贡献的理想场所。我们在纳米科学、信息学和生物科学领域都有强大的研究力量。然而，尽管相关团体在各自的领域开展了国际知名的工作，但到目前为止，某些社区之间的交流很少。我们的计划将刺激纳米信息生物界面的活动，最初借鉴道尔顿研究所（DRI）和人类运动与健康生物医学研究所（HMS）的成员。该中心最近已迁往大学主校区，拟议的方案将为建立全新的机构伙伴关系提供理想的工具。因此，我们寻求建立（和加强）计算科学家/数学家/工程师和他们的同行在自然/生命/健康科学之间的联系。我们提出了一个基层计划的细粒度的项目支持，将最大限度地提高参与的机会，并鼓励不同学科之间的偶然接触。通过在挑战驱动的框架内运作，我们将推动该计划取得切实成果，并为长期可持续发展奠定基础。

项目成果

Polyvinylpyrrolidone-coated gold nanoparticles inhibit endothelial cell viability, proliferation, and ERK1/2 phosphorylation and reduce the magnitude of endothelial-independent dilator responses in isolated aortic vessels.

• DOI: 10.2147/ijn.s133093
• 发表时间: 2017
• 期刊: International journal of nanomedicine
• 影响因子: 8
• 作者: Mohamed T;Matou-Nasri S;Farooq A;Whitehead D;Azzawi M
• 通讯作者: Azzawi M

A novel system of electrodes transparent to ultrasound for simultaneous detection of myoelectric activity and B-mode ultrasound images of skeletal muscles.

一个新型的电极系统，可与超声透明，以同时检测骨骼肌的肌电活动和B模式超声图像。

• DOI: 10.1152/japplphysiol.00090.2013
• 发表时间: 2013-10-15
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Botter A;Vieira TM;Loram ID;Merletti R;Hodson-Tole EF
• 通讯作者: Hodson-Tole EF

NanoInfoBio: A case-study in interdisciplinary research

NanoInfoBio：跨学科研究的案例研究

• 发表时间: 2012
• 作者: Jacobs, N.

Automated regional analysis of B-mode ultrasound images of skeletal muscle movement.

• DOI: 10.1152/japplphysiol.00701.2011
• 发表时间: 2012-01
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Darby J;Hodson-Tole EF;Costen N;Loram ID
• 通讯作者: Loram ID

Attenuation of endothelial-dependent vasodilator responses, induced by dye-encapsulated silica nanoparticles, in aortic vessels.

• DOI: 10.2217/nnm.12.213
• 发表时间: 2014-04
• 期刊: Nanomedicine
• 影响因子: 5.5
• 作者: Asima Farooq;Debra Whitehead;M. Azzawi