LIPEMIA-CARBOHYDRATE & GLYCERIDE METABOLISM

脂血症-碳水化合物

• 批准号: 3334239
• 负责人: GERALD M. REAVEN
• 金额: $ 18万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-01-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3334239
• 关键词: diabetes mellitus; dietary carbohydrates; dietary lipid; glucose metabolism; glucose tolerance test; glycerides; high density lipoproteins; hormone metabolism; human subject; hyperglycemia; hyperinsulinism; hypertension; hypertriglyceridemia; insulin; insulin inhibitor; insulin sensitivity /resistance; lipid biosynthesis; lipid metabolism; low density lipoprotein; noninsulin dependent diabetes mellitus; nutrition related tag; protein metabolism; very low density lipoprotein

One goal of the proposed studies will be to evaluate the possibility that resistance to insulin stimulated glucose uptake is a common defect in patients with hypertension. In order to examine this hypothesis we will attempt to confirm the presence of ambient hyperinsulinemia in patients with hypertension, and to use the insulin clamp technique to see if patients with hypertension are insulin resistant. In addition, we will measure plasma lipid and lipoprotein concentrations in patients with hypertension, both non-diabetic and diabetic, in order to examine the possibility that abnormalities of glucose and insulin metabolism are correlated with the abnormalities of lipid metabolism that have been reported to occur in association with hypertension. In this endeavor we will also control for the effects of anti-hypertensive treatment in order to differentiate between the effects of hypertension, per se, or carbohydrate and lipid metabolism, as contrasted to changes due to the treatment of hypertension. Another major objective of the proposed studies will be to assess the effects of variations in the relative proportion of dietary fat and carbohydrates on plasma glucose, insulin, lipid and lipoprotein concentrations in hypertension and non-insulin-dependent diabetes mellitus (NIDDM). Finally, we will evaluate the effects of NIDDM, before and after glycemia control, on measurements of both low density lipoprotein and high density lipoprotein kinetics.

拟议研究的一个目标是评估 对胰岛素刺激的葡萄糖摄取的抵抗是一种常见的 高血压患者的缺陷。 为了检验这个 假设我们将尝试确认环境的存在 高血压患者的高胰岛素血症，并使用 胰岛素钳夹技术，以观察高血压患者是否 胰岛素抵抗 此外，我们还将测量血脂， 高血压患者的脂蛋白浓度， 非糖尿病患者和糖尿病患者，为了检查 葡萄糖和胰岛素代谢异常与 与脂质代谢异常有关， 据报道与高血压有关。 在这 我们还将努力控制抗高血压药物的作用， 治疗，以区分效果 高血压本身，或碳水化合物和脂质代谢， 与高血压治疗引起的变化形成对比。 拟议研究的另一个主要目标是评估 膳食脂肪相对比例变化的影响 碳水化合物对血糖、胰岛素、血脂和脂蛋白的影响 高血压和非胰岛素依赖型糖尿病中的浓度 糖尿病（NIDDM）。 最后，我们将评估 NIDDM，在血糖控制前后， 低密度脂蛋白和高密度脂蛋白动力学。