LIPEMIA-CARBOHYDRATE & GLYCERIDE METABOLISM

拟议研究的一个目标将是评估这种可能性 抵抗胰岛素刺激的葡萄糖摄取是一种常见的 高血压患者的缺陷。为了检查这一点 假设我们将尝试确认周围环境的存在 高血压患者的高胰岛素血症，并使用 胰岛素钳夹技术观察高血压患者是否 胰岛素抵抗。此外，我们还将测量血脂和 高血压病患者脂蛋白水平 非糖尿病人和糖尿病人，以检查 糖代谢异常与胰岛素代谢异常相关 与脂肪代谢的异常有关 据报道与高血压有关。在这 我们还将努力控制降压的效果 治疗，以区别不同的影响 高血压本身或碳水化合物和脂肪代谢，如 与高血压治疗后的变化进行了对比。 拟议研究的另一个主要目标是评估 膳食脂肪相对比例变化的影响 和碳水化合物对血糖、胰岛素、血脂和脂蛋白的影响 高血压和非胰岛素依赖型糖尿病的血药浓度 糖尿病(NIDDM)。最后，我们将评估 NIDDM在血糖控制前后的测量 低密度脂蛋白和高密度脂蛋白的动力学。

One goal of the proposed studies will be to evaluate the possibility that resistance to insulin stimulated glucose uptake is a common defect in patients with hypertension. In order to examine this hypothesis we will attempt to confirm the presence of ambient hyperinsulinemia in patients with hypertension, and to use the insulin clamp technique to see if patients with hypertension are insulin resistant. In addition, we will measure plasma lipid and lipoprotein concentrations in patients with hypertension, both non-diabetic and diabetic, in order to examine the possibility that abnormalities of glucose and insulin metabolism are correlated with the abnormalities of lipid metabolism that have been reported to occur in association with hypertension. In this endeavor we will also control for the effects of anti-hypertensive treatment in order to differentiate between the effects of hypertension, per se, or carbohydrate and lipid metabolism, as contrasted to changes due to the treatment of hypertension. Another major objective of the proposed studies will be to assess the effects of variations in the relative proportion of dietary fat and carbohydrates on plasma glucose, insulin, lipid and lipoprotein concentrations in hypertension and non-insulin-dependent diabetes mellitus (NIDDM). Finally, we will evaluate the effects of NIDDM, before and after glycemia control, on measurements of both low density lipoprotein and high density lipoprotein kinetics.