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NOVEL METHOD FOR OPTICAL COHERENCE TOMOGRAPHY AND MULTIPLEXED SENSING

光学相干断层扫描和多重传感的新方法

基本信息

批准号：
EP/H004963/1
负责人：
Adrian Podoleanu
金额：
$ 50.22万
依托单位：
University of Kent
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH004963%2F1
关键词：
NOVEL METHOD OPTICAL COHERENCE TOMOGRAPHY

项目摘要

Optical coherence tomography (OCT) allows high depth resolution imaging and has received considerable interest in the last 5 years, which resulted in a 100 times increase in the speed of operation and extension to a large variety of imaging problems. There are two main types of OCT: time domain (TD) and spectral domain (SD). The recent progress in speed has been achieved by developers working in the SD-OCT field. However, SD-OCT has several disadvantages, non present in TD-OCT. The research in SD-OCT has also stimulated the development of novel fast tunable lasers, the so called swept sources (SS). Tremendous effort has been put in understanding and controlling the phenomena in closed optical loops containing optical amplifiers for optical sources to be used in SS-OCT. The present proposal puts forward a novel type of OCT and a novel class of optical interferometers. This is driven by the needs to address the limitations in terms of speed of the TD-OCT method, by the potential of the en-face OCT, not investigated so far, in producing 3D OCT exploration and by the limitations in terms of range and dynamic focus of the SD-OCT methods as well as dispersion compensation of all OCT methods. The novel method and devices proposed are inspired by the progress in swept sources and SS-OCT. A new class of OCT systems is researched, as a marriage between the TD-OCT and SD-OCT methods. The new OCT method eliminates or ameliorate the disadvantages of the SD-OCT method. The novel method presents the generality of being compatible with both TD-OCT and SD-OCT. The applicant has demonstrated the principle of operation which guarantees the success of research. However, the marriage between the SD-OCT and TD-OCT to be researched here promises much more than what the demonstrator set-up has shown so far, therefore research support is sought to explore the multiple avenues of the novel method. This may revolutionise the field of OCT and open applications not currently possible with the present OCT technology, such as SD-OCT of objects extended in depth by more than 1 cm (eye), or en-face imaging of moving organs or tissue (of the whole retina volume in fractions of a second, with better sampling in all directions than achievable with the most advanced SD-OCT set-up). The method to be researched will allow combination of scanning regimes and modes of operation to achieve versatile functionality in measurements, in the 3D imaging of moving tissue such as the eye, heart, or moving embryos or functional/low noise imaging by making use of angular compounding or polarisation. Novel directions are opened in the instantaneous elimination of the movement effects of the tissue when determining the liquid (blood) flow profile in a vessel, in tracking the axial position of objects (cornea or retina), automatic dispersion compensation as well as improvement in the synchronism between the coherence gate and the focus in axial scanning (a problem for both types of SD-OCT methods). The method proposed is also applicable in multiplexing of sensors. Simultaneous measurements over multiple path lengths become feasible. Three proof of concept demonstrators will be assembled, for multiple imaging at different depths using en-face TD-OCT, fast and long range tracking and swept source systems for long axial scanning.

光学相干层析成像（OCT）可以实现高深度分辨率成像，并且在过去5年中受到了相当大的关注，这导致操作速度提高了100倍，并扩展到各种成像问题。OCT主要有两种类型：时域（TD）和谱域（SD）。SD-OCT领域的开发人员最近在速度方面取得了进展。然而，SD-OCT有几个缺点，而TD-OCT不存在。SD-OCT的研究也促进了新型快速可调谐激光器的发展，即所谓的扫频源（SS）。为了理解和控制SS-OCT中使用的光源中包含光放大器的闭合光环路中的现象，人们付出了巨大的努力。提出了一种新型OCT和一类新型光学干涉仪。这是由于需要解决TD-OCT方法在速度方面的限制，由于目前尚未研究的正面OCT在产生3D OCT勘探方面的潜力，以及SD-OCT方法在范围和动态焦点方面的限制以及所有OCT方法的色散补偿。这种新方法和装置的提出是受到扫频源和SS-OCT研究进展的启发。本文研究了一类新的OCT系统，即TD-OCT和SD-OCT的结合。新的OCT方法消除或改善了SD-OCT方法的缺点。该方法具有与TD-OCT和SD-OCT兼容的通用性。申请人已展示了保证研究成功的操作原理。然而，这里研究的SD-OCT和TD-OCT之间的结合比迄今为止演示器设置所显示的要多得多，因此寻求研究支持以探索新方法的多种途径。这可能会彻底改变OCT领域和现有OCT技术目前无法实现的开放应用，例如SD-OCT对深度超过1厘米的物体（眼睛）进行扫描，或对移动器官或组织进行正面成像（在不到一秒的时间内对整个视网膜体积进行扫描，在所有方向上的采样比最先进的SD-OCT设置更好）。所研究的方法将允许扫描机制和操作模式的组合，以实现多种功能的测量，在移动组织的3D成像，如眼睛，心脏，或移动胚胎或功能性/低噪声成像，通过使用角度复合或偏振。在确定血管中的液体（血液）流动轮廓时，在瞬间消除组织的运动影响，跟踪物体（角膜或视网膜）的轴向位置，自动色散补偿以及改善轴向扫描中相干门和焦点之间的同步性方面开辟了新的方向（这两种类型的SD-OCT方法都存在问题）。该方法同样适用于传感器的多路复用。同时测量多个路径长度变得可行。将组装三个概念验证演示器，使用正面TD-OCT进行不同深度的多次成像，快速远程跟踪和扫描源系统进行长轴向扫描。