RESPIRATORY MUSCLE AFFERENTS IN RESPIRATORY CONTROL

拟议研究的总体目标是确定影响 肋间肌肉本体感受器对呼吸的控制。 第一个目标是确定外部和内部的影响 肋间肌梭末梢和延髓上的肌腱器官 呼吸活动。肌梭末端将有选择地 在肌肉振动的刺激下，肌腱器官会有选择地 腹根刺激可刺激肌肉收缩。 第二个目标是确定延髓中间神经元 肋间肌肉本体感受器活动向延髓的传递 球脊髓呼吸神经元。 第三个目标是确定哪些本体感受器(主要和/或 次级肌梭末梢、肌腱器官)。 肋间内肌对膈肌有易化作用 运动活动(脊椎“肋间-膈”反射)。 了解这些特定肌肉本体感受器的反射效应 将有助于我们理解呼吸道感染的机制 肌肉活动在不同的情况下会发生变化，例如改变 姿势、胸部压缩和扩张、怀孕、肥胖、呼吸 肌肉疲劳、水浸和胸壁力学改变 由肺部疾病引起的。

The overall objective of the proposed studies is to determine the effects of intercostal muscle proprioceptors on the control of breathing. The first objective is to determine the effects of external and internal intercostal muscle spindle endings and tendon organs on medullary respiratory activity. Muscle spindle endings will be selectively stimulated by muscle vibration, and tendon organs will be selectively stimulated by ventral root stimulated muscle contraction. The second objective is to determine the medullary interneurons transmitting intercostal muscle proprioceptor activity to medullary bulbospinal respiratory neurons. The third objective is to determine which proprioceptors (primary and/or secondary muscle spindle endings, tendon organs) in lower-thoracic external and internal intercostal muscles have a facilitatory effect on phrenic motor activity (spinal "intercostal-to-phrenic" reflex). Knowledge of the reflex effects of these specific muscle proprioceptors will contribute to our understanding of the mechanisms by which respiratory muscle activity is altered undered various circumstances, such as changing posture, chest compression and expansion, pregnancy, obesity, respiratory muscle fatique, water immersion, and changes in chest wall mechanics resulting from lung diseases.