Self-Assembling Therapeutics for Specific Nanoscale Interactions with the Sodium Pump

这个项目的长期科学研究是针对新的和有效的治疗方法的制备，为了做到这一点，我们需要确保我们的新设备达到它们的生物目标，并且在我们开始一个更大的项目来指导它们的临床实践之前，已经证明了它们在特定疾病应用中的有效性。欧洲科学基金会（ESF）纳米医学展望将开发新的多功能、空间有序、结构多样的靶向药物输送系统作为优先事项。基于抗体-药物偶联物和聚合物-生物聚合物偶联物的纳米药物是增强疗效药物的关键组成部分。虽然更复杂，但这些偶联物提供了更高的多样性，导致药物与小分子化合物相比具有更高的信息含量。这允许更大的靶点特异性，改进的功能和多任务的机会，例如原位诊断和治疗，或同时作用于多个治疗靶点或疾病途径。因此，我们将在本项目中准备的新型共轭纳米器件能够独特地解决目前治疗不足的疾病。通过开发新的生物靶点和界面，我们的材料将为改善疾病带来的患者、经济和社会结果做出重要的贡献。

The long-term science for this project is directed towards the preparation of new and effective therapeutics, and to dothis we need to ensure that our novel devices hit their biological targets and have proven efficacyin a particular disease application before we can commence a larger programme to guide theirdevelopment towards clinical practice. The European Science Foundation (ESF) Nanomedicine Forward Look describes the development ofnew multifunctional, spatially ordered, architecturally-varied systems for targeted drug delivery as apriority. Nanopharmaceuticals based on antibody-drug conjugates and polymer-biopolymerconjugates are a key component of enhanced efficacy medicines. While more complex, theseconjugates offer enhanced diversity, leading to drugs with much higher information content comparedto small molecule compounds. This allows for greater target specificity, improved functionality andthe opportunity to multi-task, for example to diagnose and treat in situ, or to act on more than onetherapeutic target or disease pathway simultaneously. The novel conjugate nanodevices we willprepare in this programme are thus uniquely able to address diseases which are inadequately treatednow. By exploiting new biological targets and interfaces, our materials will contribute a vital step inimproving patient, economic and society outcomes arising from disease.