NOVEL ANTIHYPERTENSIVES: RATIONAL DESIGN AND EVALUATION

高血压是许多心血管疾病的致病因素。 因此，这是当前许多研究的重点。我们是 调查与评估--在细胞、分子酶学方面 和整个动物水平--新颖但结构简单的化合物 有可能作为降压药的自己的设计。 我们的化合物是这样设计的，在许多情况下，它们可以作为亲药物 或自杀底物，我们预计会主要影响外围设备 神经系统，尽管在某些情况下中枢影响也可能是 现在时。各种实验方法，从生物检测到 从亚细胞分级实验到酶研究，都在进行中。 希望我们的研究成果能为新建筑的设计奠定基础。 临床上有用的化合物的类别。

Hypertension is a causative factor in the genesis of many cardiovascular diseases, and is thus the focus of much current research. We are investigating and evaluating -- at the cellular, molecular enzymological and whole animal levels -- novel but structurally simple compounds of our own design which have the potential of acting as antihypertensive agents. Our compounds are designed so that in many cases they can act as pro-drugs or suicide substrates which we expect to affect principally the peripheral nervous system, although in some cases central effects may also be present. A variety of experimental approaches, ranging from bioassays to subcellular fraction experiments to enzymatic studies, are being employed. It is hoped that our results will establish the basis for design of new classes of clinically useful compounds.