NOVEL ANTIHYPERTENSIVES: RATIONAL DESIGN AND EVALUATION

高血压是许多心血管疾病的病因之一， 疾病，因此是目前许多研究的重点。 我们 研究和评价--在细胞、分子酶学 和整个动物的水平-新的，但结构简单的化合物， 自己的设计，有可能作为抗高血压药物。 我们的化合物被设计成在许多情况下可以作为前药 或我们预期主要影响外围的硅化物基质， 神经系统，虽然在某些情况下，中枢效应也可能是 礼物 各种实验方法，从生物测定到 从亚细胞级分实验到酶促研究。 希望我们的研究结果能为新的设计提供依据 临床上有用的化合物的种类。

Hypertension is a causative factor in the genesis of many cardiovascular diseases, and is thus the focus of much current research. We are investigating and evaluating -- at the cellular, molecular enzymological and whole animal levels -- novel but structurally simple compounds of our own design which have the potential of acting as antihypertensive agents. Our compounds are designed so that in many cases they can act as pro-drugs or suicide substrates which we expect to affect principally the peripheral nervous system, although in some cases central effects may also be present. A variety of experimental approaches, ranging from bioassays to subcellular fraction experiments to enzymatic studies, are being employed. It is hoped that our results will establish the basis for design of new classes of clinically useful compounds.