MODULATION OF BARORECEPTOR REFLEXES

压力感受器反射的调节

• 批准号: 3337920
• 负责人: ALLYN L. MARK
• 金额: $ 10.82万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-12-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3337920
• 关键词: angiography; baroreceptors; cardiovascular disorder; cardiovascular pharmacology; coronary artery; dietary mineral; heart failure; heart rate; human subject; hypertension; hypotension; lidocaine; male; plethysmography; renin; vascular resistance; vasopressins

Research in animals has demonstrated that carotid baroreceptor regulation of vascular resistance, heart rate, and humoral mechanisms is influenced by interaction with factors such as cardiopulmonary baroreceptors, somatic receptors, and sodium intake. It is important to study these interactions in humans for several reasons: first, there are significant species differences in reflex control of circulation and second, knowledge of these interactions holds potential for improved understanding of mechanisms and treatment of human cardiovascular disorders such as hypertension, heart failure, and hypotension. In addition, refinements in techniques for study of reflex control afford the opportunity to examine the modulation of carotid baroreflex in humans. These techniques include the new Milan neck chamber for study of responses to inhibition (neck pressure) and stimulation (neck suction) of carotid baroreceptors. The goal of the proposed research is to characterize the modulation and interactions of the carotid baroreflex in humans. There are four major objectives: The first is to study the influence of cardiopulmonary baroreceptor reflexes on carotid baroreflex control of vascular resistance, heart rate, renin and ADH using the neck chamber to alter carotid baroreceptor activity and lower body suction to inhibit cardiopulmonary receptors. The second is to determine if carotid baroreceptors modulate the somatic pressor reflex during sustained handgrip and to see if carotid baroreflex modulation of somatic pressor reflex is impaired in hypertension. The third is to compare the influence of low and high sodium intake on effectiveness of the carotid baroreflex in normotensive and hypertensive humans. The fourth is to test the concept of selective pharmacologic sensory modulation in humans by determining if intravenous infusion of lidocaine can block reflexes originating in cardiac receptors without blocking carotid baroreceptor reflexes.

动物研究表明，颈动脉压力感受器调节 血管阻力、心率和体液机制受以下因素影响 与心肺压力感受器、躯体等因素相互作用 受体和钠摄入量。研究这些相互作用是很重要的 人类有几个原因：首先，在 第二，对循环的反射控制，这些相互作用的知识成立 改善对人类疾病机制和治疗的理解的潜力 心血管疾病，如高血压、心力衰竭和低血压。 此外，反射控制研究技术的改进提供了 研究人类颈动脉压力感受器反射调制的机会。这些 技术包括新的米兰颈部小室，用于研究对 颈动脉的抑制(颈部压力)和刺激(颈部抽吸) 压力感受器。 拟议研究的目标是表征调制和 人类颈动脉压力感受器反射的相互作用。有四个主要的 目的：一是研究心肺压力感受器的影响 颈动脉压力感受性反射对血管阻力、心率、肾素的控制 和ADH利用颈腔改变颈动脉压力感受器活动和降低 身体抽吸抑制心肺感受器。二是确定 持续状态下颈动脉压力感受器是否调节躯体升压反射 并观察颈动脉压力感受性反射对躯体升压反射的调节作用 在高血压中受损。三是比较低工资和低工资的影响。 高钠摄入对血压正常人群颈动脉压力感受性反射的影响 以及高血压患者。四是检验选择性的概念 通过确定静脉注射是否对人体进行药理学感觉调节 输注利多卡因可阻断起源于心脏受体的反射 而不会阻碍颈动脉压力感受器反射。