MODULATION OF BARORECEPTOR REFLEXES

动物研究表明，颈动脉压力感受器调节 血管阻力、心率和体液机制受到以下因素的影响： 与诸如心肺压力感受器、躯体压力感受器、 受体和钠摄入量。 重要的是要研究这些相互作用， 人类有几个原因：首先， 第二，对这些相互作用的了解 提高对人类免疫缺陷机制和治疗的认识的潜力 心血管疾病，如高血压、心力衰竭和低血压。 此外，反射控制研究技术的改进， 有机会检查人类颈动脉压力感受器反射的调制。 这些 技术包括新的米兰颈室研究的反应， 颈动脉的抑制（颈部压力）和刺激（颈部抽吸） 压力感受器 所提出的研究的目标是表征调制和 人类颈动脉压力感受器反射的相互作用。 有四大 目的：一是研究心肺压力感受器的影响 对颈动脉压力感受性反射的反射控制血管阻力、心率、肾素 和ADH使用颈室来改变颈动脉压力感受器活性， 身体吸力抑制心肺受体。 二是确定 如果颈动脉压力感受器在持续性的 观察颈动脉压力感受性反射对躯体加压反射的调节作用 在高血压中受损。 三是比较低、 高钠摄入对正常血压者颈动脉压力感受性反射的影响 和高血压的人。 四是测试选择性的概念 通过确定静脉内注射是否能改善人体的药理学感觉调节 输注利多卡因可阻断源自心脏感受器的反射 而不阻断颈动脉压力感受器反射。

Research in animals has demonstrated that carotid baroreceptor regulation of vascular resistance, heart rate, and humoral mechanisms is influenced by interaction with factors such as cardiopulmonary baroreceptors, somatic receptors, and sodium intake. It is important to study these interactions in humans for several reasons: first, there are significant species differences in reflex control of circulation and second, knowledge of these interactions holds potential for improved understanding of mechanisms and treatment of human cardiovascular disorders such as hypertension, heart failure, and hypotension. In addition, refinements in techniques for study of reflex control afford the opportunity to examine the modulation of carotid baroreflex in humans. These techniques include the new Milan neck chamber for study of responses to inhibition (neck pressure) and stimulation (neck suction) of carotid baroreceptors. The goal of the proposed research is to characterize the modulation and interactions of the carotid baroreflex in humans. There are four major objectives: The first is to study the influence of cardiopulmonary baroreceptor reflexes on carotid baroreflex control of vascular resistance, heart rate, renin and ADH using the neck chamber to alter carotid baroreceptor activity and lower body suction to inhibit cardiopulmonary receptors. The second is to determine if carotid baroreceptors modulate the somatic pressor reflex during sustained handgrip and to see if carotid baroreflex modulation of somatic pressor reflex is impaired in hypertension. The third is to compare the influence of low and high sodium intake on effectiveness of the carotid baroreflex in normotensive and hypertensive humans. The fourth is to test the concept of selective pharmacologic sensory modulation in humans by determining if intravenous infusion of lidocaine can block reflexes originating in cardiac receptors without blocking carotid baroreceptor reflexes.