CARDIOVASCULAR BEHAVIOR AND THE RELAXATION RESPONSE

目的是更好地了解高血压是如何 受到放松反应的影响。 具体目标 是评估a）定期启发的效果， 对血浆去甲肾上腺素反应性的舒张反应， 未用药高血压患者对苯肾上腺素的瞳孔反应 并将这些发现与以前在 正常血压受试者; B）定期激发的影响， 松弛反应对血浆去甲肾上腺素反应性的影响 高血压患者对心理应激的反应 将结果与直立位和 等长压力; c）经常性的降压效果 未用药高血压患者舒张反应的诱发 及其对其他心血管危险因素的影响;以及d） 肾素钠和心理状况在降低血压中的价值 在未经药物治疗的高血压患者中， 松弛反应 为了实现这些特定目标，我们进行了一项随机、前瞻性对照研究。 将进行交叉调查。 血液测量 血压、心率、血浆去甲肾上腺素水平、血浆肾素活性， 瞳孔对苯乙哌啶的反应，和心理特征将是 贯彻 这项研究的重要性在于， 更好地理解所涉及的机制，并在 使用现在推荐的高血压行为治疗，也就是说， 这些技巧能引起放松反应。 高血压是一种健康 这种疾病在美国折磨着6000多万人， 心脏病发作、中风和其他血管疾病 疾病--当今这个国家死亡的主要原因。

The objectives are the better understanding of how hypertension is influenced by elicitation of the relaxation response. The specific aims are the evaluation of a) the effects of regular elicitation of the relaxation response on plasma norepinephrine responsivity and pupillary-response to phenylephrine in unmedicated hypertensive patients and the comparison of the findings to those observed previously in normotensive subjects; b) the effects of regular elicitation of the relaxation response on plasma norepinephrine responsivity in unmedicated hypertensive patients in response to psychological stress and the comparison of the results to those obtained in response to orthostatic and isometric stress; c) the blood-pressure lowering effects of the regular elicitation of the relaxation response in unmedicated hypertensive patients and its effects on other cardiovascular risk factors; and d) the predictive value of renin-sodium and psychological profiles in blood-resssure lowering in unmedicated hypertensive patients who are taught to regularly elicit the relaxation response. To accomplish these specific aims, a randomized, prospective controlled cross-over investigation will be performed. Measurements of blood pressure, heart rate, plasma norepinephrine levels, plasma renin activity, pupillary-response to phenylephrine, and psychological profiles will be carried out. The significance of this proposed research is that it is important to understand better the mechanisms involved and to be more specific in the use of the now-recommended behavioral treatments of hypertension, that is, techniques that elicit the relaxation response. Hypertension is a health disorder that afflicts over 60 million individuals in the United States and significantly contributes to heart attacks, strokes and other vascular disorders--the major causes of death in this country today.