Mechanisms & Therapeutic Effects of Relaxation Response

机制

• 批准号: 7122311
• 负责人: HERBERT BENSON
• 金额: $ 191.69万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122311
• 关键词: adrenocorticotropic hormone; alternative medicine; behavior therapy; behavioral /social science research tag; breast neoplasms; clinical research; clinical trials; cortisol; cytokine; emotions; epilepsy; epinephrine; functional /structural genomics; functional magnetic resonance imaging; human subject; human therapy evaluation; hypertension; longitudinal human study; menopause; neural plasticity; nitric oxide; norepinephrine; patient oriented research; quality of life; relaxation; stress; stress management

DESCRIPTION (provided by applicant): The long term objectives of this project are to generate knowledge through basic and clinical research on the relaxation response (RR), a physiological mind/body state opposite to that of stress that is characterized by decreased metabolism, blood pressure, heart and respiratory rates, slower brain waves and specific changes in brain activity. Since over 60% of patient visits to health care professionals in the US are related to stress and, since the RR has been demonstrated to be an effective treatment for stress-related disorders (such as hypertension, pain and mood disturbances), the biochemical, molecular and genomic bases of the RR should be better understood as well as should its clinical applications. This project is designed to improve the quality of life that has been adversely affected by stress as put forth in Healthy People 2000 and 2010. Current Specific Aims: Through a series of randomized, controlled, prospective investigations, we plan to extend further the results of our ongoing projects that include the RR's effects on: Project 1- brain mechanisms including plasticity and specific brain regions as measured by functional magnetic resonance imaging. Project 2- the molecular (nitric oxide), and biochemical (epinephrine, norepinephrine, cortisol, ACTH, cytokines) parameters that counteract the effects of acute stress in healthy adults. Project 3- the molecular (nitric oxide), and biochemical (epinephrine, norepinephrine, cortisol, ACTH, cytokines) parameters that counteract the effects of acute stress in the elderly. Project 4- hypertension in elderly patients and on the reduction of their anti hypertensive medications. Project 5- the genomic, molecular and biochemical parameters in healthy adults with either long-term or limited RR experience. Other specific aims include the initiation of 2 pilot projects that are also both randomized, controlled, prospective investigations and include the RR's effects on: Project 6- the frequency of seizures and biochemical parameters (cortisol and cytokines) in refractory epilepsy. Project 7- the quality of life including menopausal symptoms, and mood states as well as biochemical parameters in survivors of breast cancer.

描述（由申请人提供）：该项目的长期目标是通过对放松反应（RR）的基本和临床研究来产生知识，这是一种生理心理/身体状态，与压力相反，其代谢，血压，心脏和呼吸速度降低，脑和呼吸速度降低，脑脑浪潮和脑活动的特定变化。由于超过60％的患者访问美国的医疗保健专业人员与压力有关，而且由于RR已被证明是与压力有关的疾病（例如高血压，疼痛和情绪障碍）的有效治疗方法，因此，RR的生化，分子和基因组基础应以其临床应用更好地理解。该项目旨在改善健康人2000年和2010年所提出的压力不利影响的生活质量。 当前的具体目的：通过一系列随机，受控，前瞻性研究，我们计划进一步扩展我们正在进行的项目的结果，包括RR对：通过功能磁共振成像衡量的项目1-大脑机制，包括可塑性和特定的大脑区域。项目2-分子（一氧化氮）和生化（肾上腺素，去甲肾上腺素，皮质醇，ACTH，细胞因子）参数，这些参数抵消了健康成年人急性应激的影响。项目3-分子（一氧化氮）和生化（肾上腺素，去甲肾上腺素，皮质醇，ACTH，细胞因子）参数，这些参数抵消了老年人急性应激的影响。项目4-老年患者的高血压以及减少抗高血压药物的研究。项目5-长期或有限的RR经验的健康成年人中的基因组，分子和生化参数。其他具体目的包括启动2个试点项目，这些项目也是随机，受控的，前瞻性研究的启动，包括RR对：6-Project 6-癫痫发作和生化参数的频率（皮质醇和细胞因子）在难治性癫痫中。项目7-生活质量，包括更年期症状，情绪状态以及乳腺癌幸存者的生化参数。