DOES RELAXATION RESPONSE INHIBIT ACUTE STRESS?

放松反应可以抑制急性压力吗？

• 批准号: 7366512
• 负责人: HERBERT BENSON
• 金额: $ 0.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7366512
• 关键词: DOES; RELAXATION; RESPONSE; INHIBIT; ACUTE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The relaxation response designates a set of integrated physiologic changes that includes states of perceived well-being with reduced cortical activation on electroencephalograms (EEG) and reductions in respiratory rate, blood pressure, oxygen consumption and arterial blood lactate. This Centers for Disease Control and Prevention supported study examines how the relaxation response inhibits the physiologic changes of acute stress. It tests the hypothesis that molecular mediators of the relaxation response will counteract the biochemical and cellular changes associated with acute psychosocial stress. An additional goal is to develop techniques for studying the effects of normal physiologic variation, such as changes in breathing rate and heart rate, on functional magnetic resonance images. The hypothesis is that in a subset of structures namely the medulla, hypothalamus, amygdala and rostral anterior cingulate cortex) the fMRI signal changes will strongly correlate temporally with changes in respiratory function. Another hypothesis is that activation in the insula and lateral hypothalamus will correlate with non-linear heart rate and respiration rate complexity. The effects of decreased respiratory rate without focused attention or mantra will activate only a subset of the regions activated by the relaxation response. Specifically, the prediction is that limbic structures will not be significantly activated by this task in either group, but that primary and secondary motor cortex regions involved in volitional control of breathing will be activated.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。放松反应指的是一系列综合的生理变化，包括感觉到的健康状态，脑电(EEG)上皮质激活的减少，以及呼吸频率、血压、耗氧量和动脉血乳酸的减少。这项由疾病控制和预防中心支持的研究考察了放松反应如何抑制急性应激的生理变化。它验证了一种假设，即松弛反应的分子介体将抵消与急性心理社会应激相关的生化和细胞变化。另一个目标是开发研究正常生理变化对功能磁共振图像的影响的技术，例如呼吸频率和心率的变化。假说是，在结构的一个子集，即延髓、下丘脑、杏仁核和嘴前扣带皮质)，fMRI信号的变化将与呼吸功能的变化在时间上强烈相关。另一种假设是，脑岛和外侧下丘脑的激活将与非线性心率和呼吸频率的复杂性相关。没有集中注意力或咒语的呼吸频率减慢的效果只会激活放松反应所激活的区域的一部分。具体地说，预测是，在这两组人中，边缘结构都不会因为这项任务而显著激活，但参与呼吸意志控制的初级和次级运动皮质区域将被激活。