IN CONTACT ANALYSIS OF SYNOVIAL FLUID LUBRICATING FILM PROPERTIES

滑液润滑膜性能的接触分析

• 批准号: EP/H020837/1
• 负责人: Philippa Cann
• 金额: $ 57.93万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH020837%2F1
• 关键词: CONTACT; ANALYSIS; SYNOVIAL; FLUID; LUBRICATING

Total hip replacement is a well-established and highly successful treatment for end stage hip arthritis and in recent years there have been significant improvements in prosthetic components. However there are still concerns about performance and component life as implants are increasingly being used in younger and more active patients. Wear of the articular surfaces remains a problem and is known to be a major cause of failure in metal-polymer joints through osteolysis. Although wear is reduced significantly with the new generation of metal-on-metal joints there are concerns about the formation of nano-wear particles which lead to increased levels of chromium and cobalt in the body. Recently this problem has been accentuated by reports of 'pseudo-tumours' which are associated with high metal ion levels. Thus prosthesis wear remains an important area of research and most experimental studies have concentrated on this aspect. Relatively little attention has been paid to analysing the properties of the synovial lubricating film and the mechanisms of film formation, although such knowledge is key to the development of strategies to reduce wear. Wear of prosthetic joints is controlled by the properties of the synovial lubricating film and the nature of the articulating surface. The current proposal will focus on understanding lubrication mechanisms and the role of synovial fluid constituents in artifical hip joints.The proposed study will analyse the chemical and physical properties of synovial fluid lubricating films formed during rubbing. The project will use two analytical methods; In-contact Fluorescence Imaging and Atomic Force Microscopy to analyse the chemical composition, molecular structure and local physical properties (rheology, friction) of SF lubricating films. The analysis will be carried out 'in contact' so the film properties are measured during the lubrication process rather than post-test. The proposed work will provide information on the fundamental lubrication mechanisms occurring in artificial hip joints. The research has important implications for the development of low-wear strategies and new prosthesis designs. The primary beneficiaries will be the NHS, orthopaedic surgeons and their patients as the outcome will be improved joint life and reduced incidence of prosthesis revision. In 2007, the UK performed 10,500 THR revision operations, each of which may cost up to 25K, totalling 255 million per year. Thus a reduction in revision rate, particularly for MoM joints, is an important goal as it is a costly and demanding procedure, which already consumes 10% of the NHS joint replacement budget.The research will also deliver fundamental information of the effect of SF chemistry on joint wear. Such knowledge will enable surgeons to make an informed choice of the most appropriate type of prosthesis for each patient depending on their SF chemistry. The study could also contribute to the development of a SF 'tribo' health check and remedial strategies to improve joint lubrication. Prosthesis manufacturers will also benefit from the proposed research as a detailed understanding of the lubrication process will aid improved design of joints to reduce wear and increase implant life.

全髋关节置换术是一种成熟且非常成功的终末期髋关节炎治疗方法，近年来假体部件有了显着改进。然而，随着植入物越来越多地用于更年轻和更活跃的患者，仍然存在对性能和组件寿命的担忧。关节面的磨损仍然是一个问题，并且已知是通过骨质溶解导致金属-聚合物关节失效的主要原因。虽然新一代金属对金属接头的磨损显著减少，但人们担心纳米磨损颗粒的形成会导致体内铬和钴的含量增加。最近，这个问题已被加重的报告'假肿瘤'，这是与高金属离子水平。因此，假体磨损仍然是一个重要的研究领域，大多数实验研究都集中在这方面。相对较少的注意力已经支付给分析的性能滑液润滑膜和膜形成的机制，虽然这样的知识是关键的发展战略，以减少磨损。人工关节的磨损由滑膜润滑膜的性质和关节面的性质控制。目前的建议将集中在了解润滑机制和滑液成分在人工髋关节中的作用。拟议的研究将分析摩擦过程中形成的滑液润滑膜的化学和物理性质。该项目将使用两种分析方法：接触式荧光成像和原子力显微镜来分析SF润滑膜的化学成分，分子结构和局部物理特性（流变学，摩擦）。分析将在“接触”状态下进行，因此在润滑过程中而不是在测试后测量油膜特性。拟议的工作将提供信息的基本润滑机制发生在人工髋关节。该研究对低磨损策略和新假体设计的发展具有重要意义。主要受益者将是NHS、骨科医生及其患者，因为结果将改善关节寿命并降低假体翻修的发生率。2007年，英国进行了10，500例THR翻修手术，每例手术的费用高达25，000英镑，每年总计2.55亿英镑。因此，降低翻修率，特别是MoM关节的翻修率，是一个重要的目标，因为这是一个昂贵且要求苛刻的手术，已经消耗了NHS关节置换预算的10%。该研究还将提供SF化学对关节磨损影响的基本信息。这些知识将使外科医生能够根据其SF化学性质为每位患者选择最合适的假体类型。该研究还有助于开发SF“摩擦”健康检查和改善关节润滑的补救策略。假体制造商也将受益于拟议的研究，因为对润滑过程的详细了解将有助于改进关节设计，以减少磨损并延长植入物寿命。

项目成果

On the matter of synovial fluid lubrication: implications for Metal-on-Metal hip tribology.

• DOI: 10.1016/j.jmbbm.2013.12.016
• 发表时间: 2014-06
• 期刊: Journal of the mechanical behavior of biomedical materials
• 影响因子: 3.9
• 作者: C. Myant;P. Cann

Inlet protein aggregation: a new mechanism for lubricating film formation with model synovial fluids.

• DOI: 10.1177/0954411911401306
• 发表时间: 2011-07
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Fan J;Myant CW;Underwood R;Cann PM;Hart A
• 通讯作者: Hart A

The effect of transient conditions on synovial fluid protein aggregation lubrication.

• DOI: 10.1016/j.jmbbm.2014.02.005
• 发表时间: 2014-06
• 期刊: Journal of the mechanical behavior of biomedical materials
• 影响因子: 3.9
• 作者: C. Myant;P. Cann

In contact observation of model synovial fluid lubricating mechanisms

• DOI: 10.1016/j.triboint.2012.04.029
• 发表时间: 2013-07-01
• 期刊: TRIBOLOGY INTERNATIONAL
• 影响因子: 6.2
• 作者: Myant, Connor;Cann, Philippa
• 通讯作者: Cann, Philippa

The effect of transient motion on Isoviscous-EHL films in compliant, point, contacts

• DOI: 10.1016/j.triboint.2013.11.019
• 发表时间: 2014-04
• 期刊: Tribology International
• 影响因子: 6.2
• 作者: C. Myant;M. Fowell;P. Cann