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FACTORS AFFECTING EXERCISE INDUCED BRONCHOSPASM

影响运动诱发支气管痉挛的因素

基本信息

批准号：
3339903
负责人：
FRANCOIS HAAS
金额：
$ 8.61万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-07-01 至 1986-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3339903
关键词：
asthma bronchospasm climate diving /swimming environmental adaptation exercise human subject physical fitness

项目摘要

Asthma is the second leading cause of functional limitation in the under 45-year-old age group. The acute exacerbation of symptomes by physical exertion to which these patients are susceptible can be further exacerbated by a cold and/or dry environment. There is compelling evidence that the mechanism for bronchoconstriction is loss of heat from the airways with consequent cooling of the respiratory tract. During exercise, however, both asthnatics and normal subjects demonstrate an increased expiratory flow which is most likely due to both bronchodilation and increased elastic recoil of the lung. It would appear, therefore, that the mechanism responsible for this increase in airflow serves as a competetive mechanism to exercise-induced bronchospasm (EIB). Swim training decreases overall asthma disability scores and use of medicine but does not diminish EIB severity. Run training appears to accomplish these benefits and also to reduce EIB. We hypothesize that the difference between these two forms of training is a difference in adaptive respiration stimulus. Running results in an increase in threshold to airway cooling due to an adaptive process in the respiratory tract from repeated bouts of hyperpnea under a broad range of climatic conditions. The warm, humid swimming pool environment would not provide a sifficiently adaptive stimulus. The aim of this project is to asses the roles in EIB of physical fitness and/or airway adaptation to cooling via swim and run training plus eucapnic hyperpnea in a three-way crossover design.

哮喘是第二个主要原因的功能限制在下 45岁年龄组。急性加重的疾病，由物理这些患者易受影响的运动可能会进一步加剧寒冷和/或干燥的环境。确凿证明支气管收缩的机制是气道的热量损失，从而冷却呼吸道。然而，在锻炼过程中，哮喘患者和正常受试者都表现出呼气增加最有可能是由于支气管扩张和弹性增加引起的流动肺回缩。因此，该机制似乎负责这种增加的气流作为一个竞争机制运动诱发支气管痉挛（EIB）。游泳训练整体下降哮喘残疾评分和药物使用，但不会减少EIB 严重性。跑步训练似乎可以实现这些好处，降低EIB。我们假设，这两种形式之间的差异训练是适应性呼吸刺激的差异。运行结果在由于自适应过程导致气道冷却阈值增加中，呼吸道反复发作的呼吸过度在一个广泛的范围的气候条件。温暖潮湿的游泳池环境将不能提供有效的适应性刺激。本项目的目的是评估身体健康和/或气道适应在EIB中的作用，通过游泳和跑步训练加上三种方式的正常二氧化碳呼吸过度来降温交叉设计

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of aerobic training on forced expiratory airflow in exercising asthmatic humans.

有氧训练对哮喘患者用力呼气气流的影响。

DOI：
10.1152/jappl.1987.63.3.1230
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
0
作者：
Haas,F;Pasierski,S;Levine,N;Bishop,M;Axen,K;Pineda,H;Haas,A
通讯作者：
Haas,A

Aerobic capacity in spinal cord injured people.

脊髓损伤者的有氧能力。

DOI：
10.1089/cns.1986.3.77
发表时间：
1986
期刊：
Central nervous system trauma : journal of the American Paralysis Association
影响因子：
0
作者：
Haas,F;Axen,K;Pineda,H
通讯作者：
Pineda,H

Reduced hyperpnea-induced bronchospasm following repeated cold air challenge.

减少反复冷空气挑战后呼吸过度引起的支气管痉挛。