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Hybrid Materials for the Enzymatic Reduction of Carbon-Dioxide

用于酶促还原二氧化碳的混合材料

基本信息

批准号：
EP/H026304/1
负责人：
Petra Cameron
金额：
$ 13.45万
依托单位：
University of Bath
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH026304%2F1
关键词：
Hybrid Materials Enzymatic Reduction Carbon

项目摘要

Enzymes are the catalysts of choice for sustainable and organic solvent free chemical transformations, but there remain issues with the lack of stability and loss of activity of enzymes if their environment is not carefully controlled. In this project new bio-catalytic materials will be synthesised and characterised. The aim is to create robust enzyme-containing materials that have high activity for the reduction of carbon dioxide. Thin hydrogel layers (nm to mm thick) will be grown on solid supports for applications in supported enzyme catalysis. The hydrogel films will be created by the surface initiated ordering of di-peptide amphiphiles into hydrogel matrices both on flat surfaces and inside porous materials. Enzyme stability and activity will be improved in three ways. (1) The activity and stability of enzymes from both mesophiles (organisms that live in moderate environments) and extremophiles (organisms that thrive under extreme conditions) will be compared. (2) The enzyme will be immobilised in a peptide hydrogel matrix that mimics the extracellular matrix in biological organisms. The peptide gel will be a surface bound gel that has an open (99% water by volume) structure ideal for immobilising enzymes while still allowing the diffusion of small molecules in and out. In addition the gel will provide a locally controlled pH environment and prevent unfolding of the protein. (3) To improve stability still further and create a robust material, the hydrogel will be self-assembled on the internal surface area of a highly porous inorganic oxide film. The final product will be an integrated catalytic material that reduces carbon dioxide to formic acid and other useful organic feedstock molecules.

酶是可持续和有机无溶剂化学转化的首选催化剂，但如果不仔细控制环境，酶的稳定性和活性损失仍然存在。在这个项目中，将合成和表征新的生物催化材料。其目的是创造出具有高二氧化碳还原活性的坚固的含酶材料。薄的水凝胶层(纳米到毫米厚)将生长在固体载体上，用于负载酶催化。水凝胶膜将通过表面引发的双肽两亲分子有序形成水凝胶基质而形成，无论是在平面上还是在多孔材料内部。酶的稳定性和活性将从三个方面得到改善。(1)将比较中温微生物(生活在中等环境中的生物体)和极端微生物(在极端条件下生长的生物体)的酶的活性和稳定性。(2)该酶将被固定在模拟生物体内细胞外基质的多肽水凝胶基质中。多肽凝胶将是一种表面结合的凝胶，具有开放的(99%体积分数的水)结构，非常适合固定酶，同时仍允许小分子扩散进出。此外，凝胶将提供一个局部控制的pH环境，并防止蛋白质的展开。(3)为了进一步提高稳定性并创造出坚固的材料，水凝胶将在高度多孔的无机氧化膜的内表面积上自组装。最终产品将是一种综合催化材料，可以将二氧化碳还原为甲酸和其他有用的有机原料分子。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Azetidinium lead iodide for perovskite solar cells

DOI：
10.1039/c7ta07545f
发表时间：
2017-03
期刊：
Journal of Materials Chemistry
影响因子：
0
作者：
S. Pering;W. Deng;J. Troughton;R. Niemann;F. Brivio;P. Kubiak;Florence E. Jeffrey;T. Watson;P. Raithby;A. Johnson;S. Lewis;P. Cameron
通讯作者：
S. Pering;W. Deng;J. Troughton;R. Niemann;F. Brivio;P. Kubiak;Florence E. Jeffrey;T. Watson;P. Raithby;A. Johnson;S. Lewis;P. Cameron

Partial cation substitution reduces iodide ion transport in lead iodide perovskite solar cells