VIRAL INDUCED ALTERATIONS IN POSTNATAL PULMONARY GROWTH

病毒引起的产后肺部生长改变

• 批准号: 3345359
• 负责人: WILLIAM L CASTLEMAN
• 金额: $ 7.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1992-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3345359
• 关键词: Paramyxoviridae disease; acetylcholine; autoradiography; cell growth regulation; disease /disorder model; disease /disorder proneness /risk; emphysema; growth /development; guinea pigs; histopathology; immunoregulation; infant animal; laboratory rat; lung; lung alveolus; lymphocyte; parainfluenza virus type 1; postnatal growth disorder; respiratory airway volume; respiratory function; respiratory infections; scanning electron microscopy; viral pneumonia; virus replication

The objective of this research is to investigate the cellular and tissue mechanisms responsible for bronchiolar hypoplasia and alveolar dysplasia that result from viral bronchiolitis and pneumonia during early life. Rats infected with parainfluenza type 1 (Sendai) virus are the animal model used. Morphometric and autoradiographic methods are being used to investigate changes in cell proliferation and cell numbers that occur during postnatal lung growth and that are altered by viral-induced tissue damage and inflammation. In addition, the long-term effects of viral bronchiolitis on pulmonary function and airway hyperreactivity in rats are being assessed. Inbred strains of rats that vary in their susceptibility to viral bronchiolitis will be identified for future studies aimed at investigating genetic and immunological mechanisms that are important in controlling the development of pathologic sequelae to viral bronchiolitis in infancy.

本研究的目的是探讨细胞和 细支气管发育不全的组织机制， 由病毒性细支气管炎引起的肺泡发育不良， 早年患肺炎。 副流感病毒感染大鼠 1型（仙台）病毒是使用的动物模型。 形态测定 放射自显影方法被用来研究 细胞增殖和细胞数量的变化， 出生后肺生长，并被病毒诱导的组织改变 损伤和炎症。 此外，长期影响 病毒性毛细支气管炎对肺功能和气道的影响 正在评估大鼠的高反应性。 近交系大鼠 对病毒性细支气管炎易感性各不相同， 确定为未来的研究，旨在调查遗传和 免疫学机制在控制 病毒性细支气管炎病理后遗症的发展 婴儿期。