VIRAL INDUCED ALTERATIONS IN POSTNATAL PULMONARY GROWTH

病毒引起的产后肺部生长改变

• 批准号: 3345363
• 负责人: WILLIAM L CASTLEMAN
• 金额: $ 7.65万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3345363
• 关键词: Paramyxoviridae disease; acetylcholine; autoradiography; cell growth regulation; disease /disorder model; disease /disorder proneness /risk; emphysema; growth /development; guinea pigs; histopathology; immunoregulation; infant animal; laboratory rat; lung; lung alveolus; lymphocyte; parainfluenza virus type 1; postnatal growth disorder; respiratory airway volume; respiratory function; respiratory infections; scanning electron microscopy; viral pneumonia; virus replication

The objective of this research is to investigate the cellular and tissue mechanisms responsible for bronchiolar hypoplasia and alveolar dysplasia that result from viral bronchiolitis and pneumonia during early life. Rats infected with parainfluenza type 1 (Sendai) virus are the animal model used. Morphometric and autoradiographic methods are being used to investigate changes in cell proliferation and cell numbers that occur during postnatal lung growth and that are altered by viral-induced tissue damage and inflammation. In addition, the long-term effects of viral bronchiolitis on pulmonary function and airway hyperreactivity in rats are being assessed. Inbred strains of rats that vary in their susceptibility to viral bronchiolitis will be identified for future studies aimed at investigating genetic and immunological mechanisms that are important in controlling the development of pathologic sequelae to viral bronchiolitis in infancy.

这项研究的目的是调查细胞和 细支气管性发育不全的组织机制 病毒性毛细支气管炎和肺炎引起的肺泡发育不良 早年的肺炎。感染副流感的大鼠 使用的动物模型为1型(仙台)病毒。形态测量学 和放射自显影的方法被用来调查 过程中细胞增殖和细胞数量的变化 出生后肺生长和病毒诱导的组织改变 损伤和炎症。此外，长期的影响， 病毒性毛细支气管炎对肺功能和呼吸道的影响 正在对大鼠的高反应性进行评估。近交系大鼠 对病毒性毛细支气管炎易感性不同的人将是 确定用于未来的研究，旨在研究遗传和 免疫机制在控制病毒感染中起重要作用 病毒性毛细支气管炎的病理后遗症进展 婴儿期。

项目成果

Pulmonary eosinophilia and granulomatous pulmonary arteritis induced in rats by intravenous Sephadex.

静脉注射葡聚糖凝胶诱导大鼠肺嗜酸性粒细胞增多和肉芽肿性肺动脉炎。

• DOI: 10.1177/030098589002700401
• 发表时间: 1990
• 期刊: Veterinary pathology
• 影响因子: 2.4
• 作者: Sorden,SD;LemanskeJr,RF;Castleman,WL
• 通讯作者: Castleman,WL

Viral bronchiolitis during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness.

• 发表时间: 1990-10
• 期刊: The American journal of pathology
• 作者: William L. Castleman;R. Sorkness;R. Lemanske;P. Mcallister

Pathogenesis of bronchiolitis and pneumonia induced in neonatal and weanling rats by parainfluenza (Sendai) virus.

副流感（仙台）病毒引起的新生和断奶大鼠细支气管炎和肺炎的发病机制。

• 发表时间: 1987
• 期刊: The American journal of pathology
• 作者: Castleman,WL;Brundage-Anguish,LJ;Kreitzer,L;Neuenschwander,SB
• 通讯作者: Neuenschwander,SB

Replication of parainfluenza (Sendai) virus in isolated rat pulmonary type II alveolar epithelial cells.

副流感（仙台）病毒在分离的大鼠 II 型肺泡上皮细胞中的复制。

• 发表时间: 1989
• 期刊: The American journal of pathology
• 作者: Castleman,WL;Northrop,PJ;McAllister,PK
• 通讯作者: McAllister,PK

Asthma and Exercise

哮喘与运动

• DOI: 10.1159/000062221
• 发表时间: 2002
• 期刊: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
• 作者: R. Tan;S. Spector
• 通讯作者: S. Spector