GENES CONTROLLING VIRUS INDUCED ASTHMA IN RATS

控制病毒引起大鼠哮喘的基因

• 批准号: 6390059
• 负责人: WILLIAM L CASTLEMAN
• 金额: $ 32.33万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-10 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390059
• 关键词: allergens; asthma; atopy; disease /disorder etiology; genetic mapping; genetic strain; genetic susceptibility; immunogenetics; inflammation; laboratory rat; parainfluenza virus type 1; quantitative trait loci; respiratory hypersensitivity; respiratory infections

The long-term goal of this research is to increase understanding of basic genetic mechanisms controlling susceptibility of children to asthma following viral infection and allergen exposure. The research will use a rat model of virus-induced and allergen-accentuated asthma. Genetically-susceptible BN rats and resistant F344 rats will be studied following parainfluenza virus type 1 (Sendai) virus infection and repeated ovalbumin exposure. The specific aims are: 1) To evaluate the relative contributions of viral infection and recurrent airway allergen exposure during early life on the development of chronic airway inflammation and remodeling and airway hyperresponsiveness in atopic and non-atopic rats (BN and F344); 2) To identify genetic loci (quantitative trait loci-QTLs) controlling susceptibility to virus-induced and allergen-accentuated airway inflammation and asthma-like phenotypes using genome-wide scan and linkage analysis in (BN X F344) F1 and backcross rats; and 3) To develop congenic rat strains with chromosomal segments containing loci that control susceptibility to virus and allergen-induced asthma-like syndrome for subsequent fine chromosomal mapping studies and identification of specific genes controlling development of asthma-like phenotype.

这项研究的长期目标是增加对