QUANTITATIVE GENETIC STUDY OF LRC FAMILY DATA

LRC家系数据的定量遗传学研究

• 批准号: 3346441
• 负责人: DABEERU C RAO
• 金额: $ 17.85万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-07 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3346441
• 关键词: blood vessel disorder; congenital blood protein disorder; human population genetics; hypolipoproteinemia; lipoprotein disorder

The proposed research develops and applies appropriate methodology for the detection of major loci and the resolution of genetic and familial environmental effects on several phenotypes of importance to coronary heart disease (CHD), including plasma lipids and lipoprotein concentrations. Family data collected at five of the Lipid Research Clinics (LRCs) established by the National Heart, Lung, and Blood Institute (NHLBI) will be analyzed. New statistical methods will be developed for the families ascertained through probands with elevated lipid levels (non-random samples), and analyses will be performed on all data in a unified manner. Modes of inheritance will be investigated for two familial dyslipoproteinemias of considerable clinical significance: familial combined hyperlipidemia and familial primary hypoalphalipoproteinemia, two conditions known to be associated with premature CHD. Using both randomly and non-randomly ascertained data, we will especially investigate the possible major gene effects on these conditions. Specific hypotheses will be formulated and tested on the cultural and biological effects, heterogeneity among the LRCs (identifying the specific sources of such heterogeneity), familial basis for associations among the multiple risk factors, and temporal trends in family resemblance (i.e., age-dependent variation in heritabilities). They will be formulated using appropriate path models. The proposed research is expected to improve significantly our knowledge of the familial associations and interactions among the phenotypes, and to provide a systematic assessment of the familial environmental effects in diverse populations. The two unique features of this proposal are the innovative handling of both the random and non-random samples of family data, and the use of state-of-the-art models and statistical methods. It should be clarified that this proposal only complements, and does not duplicate, the ongoing efforts at the Central Patient Registry and Coordinating Center for the LRCs in Chapel Hill. It is believed that this cost-effective Public Health Research will expand understanding of a huge, expensive, resourceful, and previously collected data set.

建议的研究开发和应用适当的方法

项目成果

A genetic study of immunoglobulin E and atopic disease based on families ascertained through asthmatic children.

基于通过哮喘儿童确定的家庭进行的免疫球蛋白 E 和特应性疾病的遗传学研究。

• DOI: 10.1159/000153908
• 发表时间: 1990
• 期刊: Human heredity
• 影响因子: 1.8
• 作者: Parks,T;Felix,K;Rice,T;Subbarao,PV;Marimuthu,KM;Rao,DC
• 通讯作者: Rao,DC

Assessment of adiposity in an Indian population: familial correlations.

印度人群肥胖的评估：家族相关性。

• DOI: 10.1002/gepi.1370100206
• 发表时间: 1993
• 期刊: Genetic epidemiology
• 影响因子: 2.1
• 作者: Nirmala,A;Mitchell,LE;Rice,T;Reddy,PC;Rao,DC
• 通讯作者: Rao,DC

Familial resemblance of blood pressure with residual household environmental effects in consanguineous and nonconsanguineous families from Andhra Pradesh, India.

印度安得拉邦的近亲和非近亲家庭血压的家族相似性与残留家庭环境影响。

• 发表时间: 1992
• 期刊: Human biology
• 作者: Rice,T;Nirmala,A;Reddy,PC;Ramana,PV;Krishna,KS;Rao,DC
• 通讯作者: Rao,DC

Family resemblance for glucose tolerance in a Melanesian population, the Tolai.

美拉尼西亚托莱人的葡萄糖耐量具有家族相似性。

• DOI: 10.1159/000153862
• 发表时间: 1989
• 期刊: Human heredity
• 影响因子: 1.8
• 作者: King,H;Rao,DC;Bhatia,K;Koki,G;Collins,A;Zimmet,P
• 通讯作者: Zimmet,P

General purpose model and a computer program for combined segregation and path analysis (SEGPATH): automatically creating computer programs from symbolic language model specifications.

用于组合隔离和路径分析的通用模型和计算机程序（SEGPATH）：根据符号语言模型规范自动创建计算机程序。

• DOI: 10.1002/gepi.1370120208
• 发表时间: 1995
• 期刊: Genetic epidemiology.
• 作者: Province,MA;Rao,DC
• 通讯作者: Rao,DC