EARLY RISK PREDICTORS FOR CHRONIC PULMONARY DISEASE

慢性肺病的早期风险预测因素

• 批准号: 3350453
• 负责人: FRANK E SPEIZER
• 金额: $ 38.27万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1993-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3350453
• 关键词: adolescence (12-20); adult human (21+); atmosphere /weather; biomarker; child physical development; congenital respiratory disorder; disease /disorder proneness /risk; emphysema; human ecology; human subject; hypersensitivity; inflammation; longitudinal human study; middle childhood (6-11); questionnaires; respiratory airflow disorder; respiratory disorder diagnosis; respiratory disorder epidemiology; respiratory function; sign /symptom; spirometry; statistics /biometry; tobacco abuse; young adult human (21-34)

The overall aim of this continuing investigation in a well characterized, community-based population sample of children and adults is to study prospectively factors that modify growth and decline inpulmonary function and to identify predictors of chronic obstructive lung disease (COLD) in adult life. Extensive longitudinal information on respiratory symptoms and illnesses, cigarette smoking, demographic and household factors and measurements of pulmonary function have already been obtained on the cohort. Existing data on these factors will be supplemented by additional observations on them and by the investigation of: 1) indices of airways responsiveness (methacholine challenge, ratio of volumn specific flows derived for maximum and partial expiratory flow volume curves); and 2) indices of atopy (skin prick tests, total and antigen-specific IgE); and 3) indices of inflammation (eosinophil and leukocyte counts). Data will be collected in alternate years on half the population under study and will provide approximately 2000 person-years of observation on the cohort between ages 20-35, a period when maximal lung function level and onset of decline will occur. A variety of parametric (autoregressive and random effects) and nonparametric (smoothers) models will be used to assess ths longitudinal nature of the data in particular in regard to changes in lung function level but also for categorical symptom data. The results of these investigations should provide insights into the susceptability for the development of chronic obstructive lun8 disease hereby helping us identify individuals at increased risk of smoking. This information can then be used in the public health sphere to develop additional strategies for prevention of this important disease.

在油井中继续调查的总体目标是 以社区为基础的儿童特征人口抽样， 成人是前瞻性地研究改变生长的因素， 肺功能下降，并确定慢性 阻塞性肺疾病（COLD）在成年生活。 广泛 关于呼吸道症状和疾病的纵向信息， 吸烟、人口和家庭因素， 肺功能的测量已经在 的cohort。 关于这些因素的现有数据将 补充了关于这些问题的补充意见， 调查：1）气道反应性指标 （乙酰甲胆碱激发，推导的体积比流量比， 最大和部分呼气流量容积曲线）;和2）指数 特异性反应（皮肤点刺试验、总IgE和抗原特异性IgE）;以及 3)炎症指数（嗜酸性粒细胞和白细胞计数）。 每隔一年将收集一半人口的数据 正在研究中，将提供约2000人年的 对年龄在20 - 35岁之间的队列的观察， 肺功能水平会出现下降和发作。 各种 参数（自回归和随机效应）和非参数 （平滑）模型将用于评估其纵向性质 特别是关于肺功能变化的数据 水平，也用于分类症状数据。 这些调查的结果应能使人们了解 慢性阻塞性肺疾病的易发性 疾病，从而帮助我们确定个人的风险增加， 吸烟。这些信息可以用于公共卫生 制定更多预防战略的领域 重大疾病。