MRI OF ATHEROSCLEROTIC PLAQUE

磁共振成像(MRI)，一种非侵入性技术，归类为 不会造成重大危险，将被用来表征动脉粥样硬化 主要胸腔、腹部、盆腔和颈部血管有斑块。空间 分辨率将为0.5-0.8 mm。在这项决议中，我们将能够 评估斑块的形态及其成分。我们希望是 能够识别脂质、血栓、结缔组织的存在， 碎裂和坏死。同样可以辨认的是血管壁和 流道。斑块的成分将在试管中模拟 准备，这将是MRI的特征。血栓将会 从狗或核磁共振研究中获得。渡边的兔子和人类 接受手术的人将在体内成像，然后切除血管和 在体外成像。随后，将测量斑块成分。这个 该计划汇集了一个跨学科的工作人员团队， 包括核磁共振仪器和生物研究方面的专业知识，包括 组织分型和血流成像；外科；斑块分析；生物化学；以及 血液学。

Magnetic resonance imaging (MRI), a non-invasive technique classified as posing no significant hazards, will be used to characterize atherosclerotic plaque in the major thoracic, abdominal, pelvic and neck vessels. Spatial resolution will be 0.5-0.8mm. Within this resolution we will be able to assess the morphology of the plaque and its composition. We expect to be able to identify the presence of lipids, thrombus, connective tissue, clacification and necrosis. Also identifyable will be the vessel wall and flow channel. Components of the plaque will be modeled in test tube preparations, which will be characterized by MRI. Thrombus will be obtained from dogs or NMR studies. Watanabe rabbits and humans who are to undergo surgery will be imaged in-vivo, and then the vessels excised and imaged ex-vivo. Subsequently, plaque composition will be measured. The program brings together an interdisciplinary team of workers, which includes expertise in MRI instrumentation and biologic studies, including tissue typing and flow imaging; surgery; plaque analysis; biochemistry; and hematology.