MRI OF HUMAN CORONARY ARTERIES

人体冠状动脉 MRI

• 批准号: 3355829
• 负责人: LEON KAUFMAN
• 金额: $ 19.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3355829
• 关键词: atherosclerosis; clinical biomedical equipment; computer assisted diagnosis; coronary artery; coronary disorder; heart disorder diagnosis; human subject; magnetic resonance imaging; noninvasive diagnosis

Research on Magnetic Resonance Imaging of human coronary arteries is being carried out under a current contract from the NHLBI. We have demonstrated that MRI detects about half of the lesions found by coronary arteriography in the left main, left anterior descending, proximal circumflex, and proximal right coronary arteries. Key ingredients in achieving these results are the use heart-synchronized gating and of cycled multi-section imaging. The hardware used in this study continues to improve in performance and this offers new opportunities for technical improvements that may results in better clinical results. Also, different techniques can be explored. Specifically, we propose to investigate 1. Optimization of in-plane spatial resolution to match the needs of coronary images; 2. Investigation of the effects of section thickness on vessel conspicuity, including post-processing by selective addition of sections; 3. Increasing time resolution, to sample the position of the arteries at 50 msec rather than 100 msec intervals; 4. Angling of the imaging plane, both during acquisition and by post-processing to improve vessel visualization; 5. Using partial flip imaging to decrease signal from the myocardium and increase the signal from blood, so as to make the arteries show as positive contrast features. This component will include an analytical approach to developing the optimal sequence parameters; 6. use of phase information to detect flow; 7. Development of software to provide three-dimensional maps of the coronary vasculature; and 8. Characterization of echo planar imaging of the human coronary arteries. Technical validations will be done with normal volunteers, and clinical evaluations will be performed in patients who have undergone coronary arteriography. Because of its non-invasiveness, MRI is ideal for longitudinal studies designed to lead to an understanding of human atherosclerotic disease.

人体冠状动脉磁共振成像研究 动脉手术是根据目前的合同进行的 NHLBI。 我们已经证明 MRI 可以检测到大约一半的 冠状动脉造影发现左主干病变 前降支、近端回旋支和近端右 冠状动脉。 实现这些结果的关键因素是 使用心脏同步门控和循环多节 成像。 本研究中使用的硬件不断改进 性能，这为技术提供了新的机会 可能会带来更好的临床结果的改进。 还， 可以探索不同的技术。 具体来说，我们建议 研究1.优化面内空间分辨率以匹配 冠状动脉图像的需求； 2. 影响的调查 血管明显的截面厚度，包括后处理 通过选择性添加部分； 3. 提高时间分辨率， 以 50 毫秒而不是 100 毫秒对动脉位置进行采样 毫秒间隔； 4. 成像平面的角度，均在 采集和后处理以改善船舶可视化； 5. 使用部分翻转成像来减少来自 心肌并增加血液信号，从而使 动脉显示为正对比特征。 该组件将 包括开发最佳序列的分析方法 参数; 6.利用相位信息检测流量； 7. 开发软件以提供三维地图 冠状动脉血管系统； 8. 平面回波的表征 人类冠状动脉成像。 技术验证 将在正常志愿者中进行，临床评估将 需在接受过冠心病治疗的患者中进行 动脉造影。 由于其非侵入性，MRI 非常适合纵向检查 旨在加深对人类的理解的研究 动脉粥样硬化疾病。