MRI OF ATHEROSCLEROTIC PLAQUE

磁共振成像（MRI）是一种非侵入性技术， 不会造成重大危害，将用于表征动脉粥样硬化 胸、腹、盆腔和颈部主要血管中的斑块。 空间 分辨率为0.5-0.8mm。 根据这项决议，我们将能够 评估斑块的形态及其组成。 我们预期 能够识别脂质，血栓，结缔组织， 钙化和坏死。 还可识别的是血管壁， 流动通道 将在试管中模拟斑块的组成部分 制备，其将通过MRI表征。 血栓将 从狗或NMR研究中获得。 渡边兔子和人类谁是 接受手术将在体内成像，然后切除血管， 离体成像。 随后，将测量斑块组成。 的 该计划汇集了一个跨学科的工作人员团队， 包括MRI仪器和生物学研究方面的专业知识，包括 组织分型和流动成像;外科手术;斑块分析;生物化学;以及 血液学

Magnetic resonance imaging (MRI), a non-invasive technique classified as posing no significant hazards, will be used to characterize atherosclerotic plaque in the major thoracic, abdominal, pelvic and neck vessels. Spatial resolution will be 0.5-0.8mm. Within this resolution we will be able to assess the morphology of the plaque and its composition. We expect to be able to identify the presence of lipids, thrombus, connective tissue, clacification and necrosis. Also identifyable will be the vessel wall and flow channel. Components of the plaque will be modeled in test tube preparations, which will be characterized by MRI. Thrombus will be obtained from dogs or NMR studies. Watanabe rabbits and humans who are to undergo surgery will be imaged in-vivo, and then the vessels excised and imaged ex-vivo. Subsequently, plaque composition will be measured. The program brings together an interdisciplinary team of workers, which includes expertise in MRI instrumentation and biologic studies, including tissue typing and flow imaging; surgery; plaque analysis; biochemistry; and hematology.