MRI OF HUMAN CORONARY ARTERIES

人体冠状动脉 MRI

• 批准号: 3355832
• 负责人: LEON KAUFMAN
• 金额: $ 17.79万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3355832
• 关键词: atherosclerosis; clinical biomedical equipment; computer assisted diagnosis; coronary artery; coronary disorder; heart disorder diagnosis; human subject; magnetic resonance imaging; noninvasive diagnosis

Research on Magnetic Resonance Imaging of human coronary arteries is being carried out under a current contract from the NHLBI. We have demonstrated that MRI detects about half of the lesions found by coronary arteriography in the left main, left anterior descending, proximal circumflex, and proximal right coronary arteries. Key ingredients in achieving these results are the use heart-synchronized gating and of cycled multi-section imaging. The hardware used in this study continues to improve in performance and this offers new opportunities for technical improvements that may results in better clinical results. Also, different techniques can be explored. Specifically, we propose to investigate 1. Optimization of in-plane spatial resolution to match the needs of coronary images; 2. Investigation of the effects of section thickness on vessel conspicuity, including post-processing by selective addition of sections; 3. Increasing time resolution, to sample the position of the arteries at 50 msec rather than 100 msec intervals; 4. Angling of the imaging plane, both during acquisition and by post-processing to improve vessel visualization; 5. Using partial flip imaging to decrease signal from the myocardium and increase the signal from blood, so as to make the arteries show as positive contrast features. This component will include an analytical approach to developing the optimal sequence parameters; 6. use of phase information to detect flow; 7. Development of software to provide three-dimensional maps of the coronary vasculature; and 8. Characterization of echo planar imaging of the human coronary arteries. Technical validations will be done with normal volunteers, and clinical evaluations will be performed in patients who have undergone coronary arteriography. Because of its non-invasiveness, MRI is ideal for longitudinal studies designed to lead to an understanding of human atherosclerotic disease.

人体冠状动脉磁共振成像的研究 动脉是根据一份目前的合同从 NHLBI。我们已经证明，核磁共振可以检测到大约一半的 冠状动脉造影术发现左主干、左冠状动脉病变 前降支、旋股上段和右上段 冠状动脉。实现这些结果的关键因素是 心动同步闸门和循环多段的使用 成像。这项研究中使用的硬件在 性能，这提供了新的技术机遇 可能导致更好的临床结果的改进。另外， 可以探索不同的技术。具体来说，我们建议 研究1.面内空间分辨率的优化以匹配 冠脉成像的需求；2.对冠脉成像效果的调查 船舶凸度的截面厚度，包括后处理 通过有选择地增加部分；3.提高时间分辨率，以 以50毫秒而不是100毫秒的速度采样动脉的位置 毫秒间隔；4.成像平面的角度，在 通过采集和后处理来提高血管的可视化； 5.使用部分翻转成像来减少来自 并增加来自血液的信号，从而使 动脉呈阳性对比征象。此组件将 包括一种分析方法来开发最优序列 参数；6.使用相位信息来检测流量；7. 开发软件，以提供三维地图 冠状动脉的血管结构；8.回波平面的特征 人体冠状动脉的成像。技术验证 将在正常志愿者中进行，临床评估将 适用于接受过冠状动脉造影术的患者 动脉造影术。 由于它的非侵入性，mri是纵向扫描的理想选择。 旨在促进对人类的理解的研究 动脉粥样硬化症。