EARLY RISK PREDICTORS FOR CHRONIC PULMONARY DISEASE

慢性肺病的早期风险预测因素

• 批准号: 3350451
• 负责人: FRANK E SPEIZER
• 金额: $ 28.7万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3350451
• 关键词: atmosphere /weather; child physical development; congenital respiratory disorder; disease /disorder proneness /risk; emphysema; human subject; middle childhood (6-11); questionnaires; respiratory airflow disorder; respiratory disorder epidemiology; respiratory function; spirometry; statistics /biometry

The specific aim of this project is to study prospectively a cohort of children and their families to determine the extent to which childhood respiratory illness, childhood exposure to cigarette smoke (active and passive), familial factors (environmental/genetic) and airways hyperreactivity are risk predictors for adult chronic airways obstruction as assessed by their capacity to affect patterns of increase in lung function that accompany growth and development. The cohort will be observed annually in their homes. At each visit standardized respiratory illness, smoking and demography questionnaires will be administered. Forced expiratory volumes will be obtained with an 8-liter portable spirometer. Each year airways reactivity will be assessed in 50% of the study population using eucapneic hyperventilation with subfreezing air. Density-dependence of flow at specific lung volumes will also be evaluated in this 50% sample. The analyses of the data will focus on those epidemiologic risk factors which define impaired development of lung function during growth and excess decline of lung function during adult life. Factors which characterized the cohort at its inception will be studied to determine their ability to predict impaired growth and excessive decline of lung function. Methods of analyses will include logistic regression, Markov-type models and analyses of curves of change of lung function with growth. The proposal seeks to define early life risk predictors for CAO and thereby defined those at special risk prior to the occurrence of clinically disabling disease.

该项目的具体目的是前瞻性地研究一组