Molecular and cellular regulation of ovarian development

卵巢发育的分子和细胞调控

• 批准号: DP170100045
• 负责人: A/Prof Dagmar Wilhelm
• 金额: $ 28.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100045
• 关键词: Molecular; cellular; regulation; ovarian; development

This project aims to understand cell fate decisions during ovarian development. While scientists understand the decision to differentiate into a male-specific cell type, they do not understand differentiation into female-specific cell types. This team has identified marker genes that distinguish between different female cell types in the developing ovary, and will analyse the molecular and cellular mechanisms that drive the development of the ovary. This could provide a deeper understanding of how genes influence cell fate decisions during embryogenesis, and the technologies developed here will be widely applicable in biotechnological research.

该项目旨在了解卵巢发育过程中的细胞命运决定。虽然科学家们理解分化成男性特异性细胞类型的决定，但他们不理解分化成女性特异性细胞类型。该团队已经确定了在发育中的卵巢中区分不同雌性细胞类型的标记基因，并将分析驱动卵巢发育的分子和细胞机制。这可以更深入地了解基因如何影响胚胎发生过程中的细胞命运决定，这里开发的技术将广泛适用于生物技术研究。