N-3 FATTY ACIDS AND RESTENOSIS POST CORONARY ANGIOPLASTY
N-3 FATTY ACIDS AND RESTENOSIS POST CORONARY ANGIOPLASTY
批准号:
3353827
负责人:
ALEXANDER LEAF
金额:
$18.1万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-07-01 至 1989-06-30
关键词:
angiography arachidonate artery stenosis aspirin atherosclerosis blood chemistry blood lipid cardiography cardiovascular disorder prevention coronary artery coronary disorder diacylglycerols diet therapy dietary lipid dietary supplements dosage dosage forms eicosanoid metabolism enzyme inhibitors erythrocyte membrane fibrinolysis gas chromatography gas chromatography mass spectrometry human subject inositol phosphates intraluminal angioplasty lipid structure longitudinal human study marine animal oil membrane lipids nutrition related tag omega 3 fatty acid phosphatidate phospholipase A2 phospholipase C phospholipids plasminogen activator platelet activation prostacyclins prostaglandin endoperoxide synthase prostaglandins radionuclide imaging /scanning radiotracer therapy compliance thromboxanes vascular resistance
中文摘要
本研究的目的是描述a的长期影响
英文摘要
The object of this study is to describe the long term effects of a
dietary supplementation of n-3 fatty acids on functional and
biochemical parameters in patients with coronary heart disease
undergoing elective percutaneous transluminal angioplasty
(PTCA). We will use this clinical model to study the effects of n-
3 polyunsaturated fatty acids (PUFAs) on risk indicators of
atherosclerosis: serum lipids, platelet activation, thromboxane
and prostacyclin formation, and plasma fibrinolytic activity. We
will also study the interaction of long chain n-3 PUFAs,
precursors of 3-series eicosanoids, with aspirin, an inhibitor of
cyclooxygenase, which is used to prevent restenosis after PTCA.
We will conduct a detailed analysis of the effects of n-3 PUFAs
on initial steps of platelet activation related to the phospholipases
C and A2. We will relate the changes observed in myocardial
perfusion to effects of n-3 PUFAs on eicosanoid formation, serum
lipids, plasma fibrinolytic activity, membrane phospholipid
composition, and related enzyme systems.
Our findings in this clinical model should be relevant to increasing
the understanding of the effects of n-3 PUFAs in preventing
atherosclerotic disorders. Though epidemiologic studies indicate
an association, this prospective clinical study is designed to
demonstrate a causal relationship between n-3 PUFA ingestion
and decreased thromboatheromatous vascular disease, if such
relationship exists. The biochemical changes thought to be
associated with a preventive action of PUFAs will be monitored.
Because of a relatively high rate of restenosis (25-35 percent)
within one year post PTCA, this study is feasible.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
-
批准号:6184957
-
项目类别:
-
资助金额:$24.0万
-
财政年份:1999
-
负责人:ALEXANDER LEAF
-
依托单位:
FATTY ACID ANTIARRYTHMIA TRIAL (FAAT)
-
批准号:6165085
-
项目类别:
-
资助金额:$60.53万
-
财政年份:1999
-
负责人:ALEXANDER LEAF
-
依托单位:
HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
-
批准号:2826091
-
项目类别:
-
资助金额:$24.49万
-
财政年份:1999
-
负责人:ALEXANDER LEAF
-
依托单位:
FATTY ACID ANTIARRYTHMIA TRIAL (FAAT)
-
批准号:2805314
-
项目类别:
-
资助金额:$51.94万
-
财政年份:1999
-
负责人:ALEXANDER LEAF
-
依托单位:
HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
-
批准号:6390279
-
项目类别:
-
资助金额:$24.98万
-
财政年份:1999
-
负责人:ALEXANDER LEAF
-
依托单位:
KINETICS ABSORPTION OF N-3 POLYUNSATURATED FATTY ACIDS
-
批准号:6250233
-
项目类别:
-
资助金额:$2.24万
-
财政年份:1997
-
负责人:ALEXANDER LEAF
-
依托单位:
DO FISH OILS PREVENT RESTENOSIS POST-CORONARY ANGIOPLAST
-
批准号:3553275
-
项目类别:
-
资助金额:$145.23万
-
财政年份:1989
-
负责人:ALEXANDER LEAF
-
依托单位:
DO FISH OILS PREVENT RESTENOSIS POST-CORONARY ANGIOPLAST
-
批准号:3553276
-
项目类别:
-
资助金额:$75.0万
-
财政年份:1989
-
负责人:ALEXANDER LEAF
-
依托单位:
DO FISH OILS PREVENT RESTENOSIS POST-CORONARY ANGIOPLAST
-
批准号:3553273
-
项目类别:
-
资助金额:$106.89万
-
财政年份:1989
-
负责人:ALEXANDER LEAF
-
依托单位:
DO FISH OILS PREVENT RESTENOSIS POST-CORONARY ANGIOPLAST
-
批准号:3553274
-
项目类别:
-
资助金额:$135.21万
-
财政年份:1989
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISM OF DISEASE PREVENTION BY N 3 FATTY ACIDS
-
批准号:2882762
-
项目类别:
-
资助金额:$28.43万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISMS OF DISEASE PREVENTION BY OMEGA-3 FATTY ACIDS
-
批准号:2140307
-
项目类别:
-
资助金额:$23.63万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISMS OF DISEASE PREVENTION OF N-3 FATTY ACIDS
-
批准号:3237418
-
项目类别:
-
资助金额:$14.6万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISM OF DISEASE PREVENTION BY N 3 FATTY ACIDS
-
批准号:2377764
-
项目类别:
-
资助金额:$26.31万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISMS OF DISEASE PREVENTION BY N-3 FATTY ACIDS
-
批准号:3237420
-
项目类别:
-
资助金额:$22.55万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISMS OF DISEASE PREVENTION OF N-3 FATTY ACIDS
-
批准号:3237422
-
项目类别:
-
资助金额:$19.33万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISMS OF DISEASE PREVENTION BY N-3 FATTY ACIDS
-
批准号:3237423
-
项目类别:
-
资助金额:$22.28万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISMS OF DISEASE PREVENTION OF N-3 FATTY ACIDS
-
批准号:3237421
-
项目类别:
-
资助金额:$17.08万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISM OF DISEASE PREVENTION BY N 3 FATTY ACIDS
-
批准号:2140308
-
项目类别:
-
资助金额:$25.31万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
MECHANISMS OF DISEASE PREVENTION BY OMEGA-3 FATTY ACIDS
-
批准号:2140306
-
项目类别:
-
资助金额:$22.73万
-
财政年份:1988
-
负责人:ALEXANDER LEAF
-
依托单位:
海外基金