N-3 FATTY ACIDS AND RESTENOSIS POST CORONARY ANGIOPLASTY

这项研究的目的是描述一项长期影响 日粮中添加n-3脂肪酸对机体功能和功能的影响 冠心病患者生化指标的变化 接受择期经皮腔内血管成形术 (PTCA)。我们将利用这一临床模型来研究n-羟色胺的作用。 3多不饱和脂肪酸(PUFA)对糖尿病风险指标的影响 动脉粥样硬化：血脂、血小板活化、血栓素 前列环素的形成和血浆纤溶活性。我们 还将研究长链n-3多不饱和脂肪酸的相互作用， 3系列二十烷酸前体与阿司匹林，阿司匹林是一种 环氧合酶，用于预防PTCA术后再狭窄。 我们将对n-3个多不饱和脂肪酸的影响进行详细分析 与磷脂酶有关的血小板活化起始步骤的研究 C和A2。我们将把观察到的心肌细胞的变化联系起来 灌流n-3多不饱和脂肪酸对二十烷基类化合物形成的影响 脂类、血浆纤溶活性、膜磷脂 组成和相关的酶系统。 我们在这个临床模型中的发现应该与 对n-3多不饱和脂肪酸预防作用的认识 动脉粥样硬化性疾病尽管流行病学研究表明 作为一个协会，这项前瞻性临床研究旨在 证明n-3多不饱和脂肪酸摄入量之间的因果关系 并减少血栓动脉粥样硬化性血管疾病 关系是存在的。人们认为的生化变化是 将对与多不饱和脂肪酸预防行动相关的活动进行监测。 因为再狭窄率相对较高(25%-35%) 在PTCA术后一年内，本研究是可行的。

The object of this study is to describe the long term effects of a dietary supplementation of n-3 fatty acids on functional and biochemical parameters in patients with coronary heart disease undergoing elective percutaneous transluminal angioplasty (PTCA). We will use this clinical model to study the effects of n- 3 polyunsaturated fatty acids (PUFAs) on risk indicators of atherosclerosis: serum lipids, platelet activation, thromboxane and prostacyclin formation, and plasma fibrinolytic activity. We will also study the interaction of long chain n-3 PUFAs, precursors of 3-series eicosanoids, with aspirin, an inhibitor of cyclooxygenase, which is used to prevent restenosis after PTCA. We will conduct a detailed analysis of the effects of n-3 PUFAs on initial steps of platelet activation related to the phospholipases C and A2. We will relate the changes observed in myocardial perfusion to effects of n-3 PUFAs on eicosanoid formation, serum lipids, plasma fibrinolytic activity, membrane phospholipid composition, and related enzyme systems. Our findings in this clinical model should be relevant to increasing the understanding of the effects of n-3 PUFAs in preventing atherosclerotic disorders. Though epidemiologic studies indicate an association, this prospective clinical study is designed to demonstrate a causal relationship between n-3 PUFA ingestion and decreased thromboatheromatous vascular disease, if such relationship exists. The biochemical changes thought to be associated with a preventive action of PUFAs will be monitored. Because of a relatively high rate of restenosis (25-35 percent) within one year post PTCA, this study is feasible.