EXERCISE: CORONARY RESERVE, CORONARY HEART DISEASE

锻炼：冠状动脉储备、冠心病

• 批准号: 3351560
• 负责人: M HAROLD LAUGHLIN
• 金额: $ 8.84万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-15 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3351560
• 关键词: adenosine; biological transport; capillary bed; cardiovascular disorder prevention; coronary artery; coronary disorder; coronary vasodilator; dipyridamole; exercise; heart circulation; heart function; heart pharmacology; myocardial ischemia /hypoxia; myocardium; nutrient bioavailability; oxygen transport; papaverine; radiotracer; sympathetic nervous system; vascular endothelium permeability

Exercise training has been reported to be beneficial in preventing and/or treating coronary heart disease. However, the primary underlying mechanisms and the relative importance of training induced changes in the coronary vascular bed are not clear at this time. The major goal of the research outlined in this proposal is to provide a better understanding of the effects of exercise training on basic coronary function. Since the purpose of the coronary circulation is to transport nutrients and oxygen to the myocardial cells and to transport metabolites away from these cells, this grant focuses on the effects of training on coronary transport capacity. During the first year of this grant it was found that coronary transport capacity can be quantitated by measuring coronary blood flow reserve capacity and coronary capillary diffusion capacity. It was then found that exercise trained dogs have a large increase in coronary transport reserve in that blood flow and capillary diffusion capacities are both increased. The research outlined in this proposal will attain 5 specific aims that will determine the mechanisms responsible for and functional significance of this change: 1. Determine the mechanisms responsible for the exercise training induced increase in coronary transport reserve. 2. Determine the role of the sympathetic nervous system in the exercise training induced increase in coronary transport reserve. 3. Determine how the exercise training induced changes in the coronary vascular bed influence capillary transport during acute myocardial ischemia. 4. Determine the effects of exercise training on coronary transport reserve in minature swine. 5. Determine how the training induced increase in coronary transport reserve influences coronary transcapillary exchange and exchange capacity in conscious dogs. Transcapillary exchange will be measured with the multiple indicator diffusion technique. Coronary blood flow will be measured in conscious and anesthetized dogs with electromagnetic flow meters. Regional coronary blood flow and gross blood flow heterogeneity will be determined with the radiolabeled microsphere technique.

据报道，运动训练有助于预防和/或 治疗冠心病。 然而，主要底层 机制和训练引起的变化的相对重要性 此时冠状血管床尚不清楚。 该计划的主要目标是 本提案中概述的研究旨在提供更好的理解 运动训练对基本冠状动脉功能的影响。 自从 冠状循环的目的是将营养物质和氧气输送到 心肌细胞并将代谢物运离这些细胞， 这笔赠款的重点是训练对冠状动脉运输的影响 容量。 在这笔拨款的第一年，人们发现冠状动脉 运输能力可以通过测量冠状动脉血流量来量化 储备能力和冠状毛细血管弥散能力。 那时 发现经过运动训练的狗的冠状动脉显着增加 运输储备，血流量和毛细血管扩散能力 两者均增加。 本提案中概述的研究将达到 5 具体目标将决定负责和 这一变化的功能意义： 1. 确定引起运动训练的机制 冠状动脉运输储备增加。 2.确定交感神经系统在运动中的作用 训练引起冠状动脉运输储备的增加。 3. 确定运动训练如何引起冠状动脉的变化 血管床影响急性心肌缺血期间的毛细血管运输。 4. 确定运动训练对冠状动脉运输储备的影响 在微型猪中。 5. 确定训练如何诱导冠状动脉运输增加 储备影响冠状动脉跨毛细血管交换和交换能力 在有意识的狗中。 跨毛细管交换将用多重指示器测量 扩散技术。 冠状动脉血流量将在意识清醒和 用电磁流量计麻醉狗。 区域冠状动脉 血流量和总血流量异质性将由 放射性标记微球技术。