Changing the nature of chemical synthesis through metal catalyzed C-H bond functionalization

通过金属催化的C-H键功能化改变化学合成的性质

• 批准号: EP/I00548X/1
• 负责人: Matthew Gaunt
• 金额: $ 256.92万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI00548X%2F1
• 关键词: Changing; nature; chemical; synthesis; through

Despite the changing face of science, the importance of synthesis - the ability to make molecules - has not diminished. To solve the increasingly complex synthetic problems posed by Nature, medicine and materials, we must question the dogma that defines what we know about making organic molecules. This proposal seeks to address the 'synthesis grand challenge' to develop a new blueprint for chemical synthesis that will revolutionize the way that molecules are made in response to societies needs. In contrast to conventional synthesis, that often requires numerous chemical operations to link two molecules together, we will activate traditionally inert, but ubiquitous, carbon-hydrogen (C-H) chemical bonds with metal catalysts and transform them directly into a useful chemical architecture thereby streamlining the synthesis of natural products, medicines and materials. This will impact broadly in academia, industry and across modern society, providing (a) better ways of making molecules, (b) cheaper medicines through accelerated drug discovery, (c) advances in materials and chemical biology through chemical modification of polymers and proteins, (d) potential advances in energy related research through understanding the mechanism of hydrocarbon oxidation, and (e) an enhanced chemistry knowledge base.

尽管科学的面貌发生了变化，但合成的重要性--制造分子的能力--并没有减弱。为了解决自然、医学和材料带来的日益复杂的合成问题，我们必须质疑那些定义我们所知道的有机分子制造的教条。该提案旨在解决“合成大挑战”，为化学合成开发一个新的蓝图，这将彻底改变分子的制造方式，以满足社会需求。与通常需要大量化学操作将两个分子连接在一起的传统合成相反，我们将用金属催化剂激活传统上惰性但普遍存在的碳氢（C-H）化学键，并将其直接转化为有用的化学结构，从而简化天然产物，药物和材料的合成。这将对学术界、工业界和整个现代社会产生广泛影响，提供（a）更好的分子制造方法，（B）通过加速药物发现降低药物价格，（c）通过聚合物和蛋白质的化学改性在材料和化学生物学方面取得进展，（d）通过了解碳氢化合物氧化机制在能源相关研究方面取得潜在进展，以及（e）增强化学知识基础。

项目成果

Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts.

• DOI: 10.1021/jacs.5b03937
• 发表时间: 2015-07-01
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Cahard E;Male HP;Tissot M;Gaunt MJ
• 通讯作者: Gaunt MJ

Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P-Chiral Phosphines.

• DOI: 10.1021/jacs.6b09334
• 发表时间: 2016-10-12
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Beaud R;Phipps RJ;Gaunt MJ
• 通讯作者: Gaunt MJ