Changing the nature of chemical synthesis through metal catalyzed C-H bond functionalization

通过金属催化的C-H键功能化改变化学合成的性质

• 批准号: EP/I00548X/1
• 负责人: Matthew Gaunt
• 金额: $ 256.92万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI00548X%2F1
• 关键词: Changing; nature; chemical; synthesis; through

Despite the changing face of science, the importance of synthesis - the ability to make molecules - has not diminished. To solve the increasingly complex synthetic problems posed by Nature, medicine and materials, we must question the dogma that defines what we know about making organic molecules. This proposal seeks to address the 'synthesis grand challenge' to develop a new blueprint for chemical synthesis that will revolutionize the way that molecules are made in response to societies needs. In contrast to conventional synthesis, that often requires numerous chemical operations to link two molecules together, we will activate traditionally inert, but ubiquitous, carbon-hydrogen (C-H) chemical bonds with metal catalysts and transform them directly into a useful chemical architecture thereby streamlining the synthesis of natural products, medicines and materials. This will impact broadly in academia, industry and across modern society, providing (a) better ways of making molecules, (b) cheaper medicines through accelerated drug discovery, (c) advances in materials and chemical biology through chemical modification of polymers and proteins, (d) potential advances in energy related research through understanding the mechanism of hydrocarbon oxidation, and (e) an enhanced chemistry knowledge base.

尽管科学的面貌变化，但合成的重要性（制造分子的能力）并未降低。为了解决自然界，医学和材料构成的日益复杂的合成问题，我们必须质疑定义我们对制造有机分子的了解的教条。该建议旨在应对为化学合成的新蓝图开发新的蓝图的“综合挑战”，该蓝图将彻底改变分子对社会需求的响应方式。与常规合成相反，通常需要进行多种化学操作将两个分子连接在一起，我们将传统上激活惰性，但无处不在，碳氢（C-H）化学键与金属催化剂，并将它们直接转化为有用的化学体系结构，从而使天然产品和材料的合成流线化。这将在学术界，工业和现代社会中广泛影响（a）（a）通过加速药物发现，（b）更便宜的药物的更好方法，（c）通过化学修饰聚合物和蛋白质的化学修改材料和化学生物学的进步，（d）通过理解基础化学的能量研究，可以在能量相关的研究方面进行基础化的基础（e）基础。

项目成果

Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P-Chiral Phosphines.

• DOI: 10.1021/jacs.6b09334
• 发表时间: 2016-10-12
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Beaud R;Phipps RJ;Gaunt MJ
• 通讯作者: Gaunt MJ

Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts.

• DOI: 10.1021/jacs.5b03937
• 发表时间: 2015-07-01
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Cahard E;Male HP;Tissot M;Gaunt MJ
• 通讯作者: Gaunt MJ