CARDIOVASCULAR PHARMACOLOGY OF ATRIAL NATRIURETIC FACTOR

心房钠尿因子的心血管药理学

基本信息

  • 批准号:
    3352432
  • 负责人:
  • 金额:
    $ 17.2万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1987
  • 资助国家:
    美国
  • 起止时间:
    1987-04-01 至 1991-03-31
  • 项目状态:
    已结题

项目摘要

Atrial natriuretic factor (ANF) is a polypeptide hormone which exhibits potent natriuretic, diuretic and vascular smooth muscle- relaxing actions. Animal studies indicate that mechanical or volume-induced atrial stretch, sodium loading, and vasopressor agonists stimulate the release of ANF. Bolus infusions cause a brief fall in blood pressure which precedes the diuresis and natriuresis stimulated by ANF. Overall, the studies in animals suggest that ANF functions as a volume-regulatory hormone in concert with the actions of antidiuretic hormone and aldosterone. To date, human studies with ANF have shown diuretic and natriuretic actions of single bolus infusions of ANF, with no studies of the mechanisms and stimuli which regulate release of ANF. In our preliminary studies, a high salt diet promoted a weight gain-related increase in plasma ANF concentrations. Upright posture provoked a fall in plasma ANF, suggesting that right sided filling pressures regulate ANF release. In cardiac catheterization studies we found a marked increase in plasma ANF concentrations in the right atrium, and the ANF levels correlated positively with atrial pressure. Elevation of the legs increased atrial pressure and stimulated an increase in secretion rate of ANF across the heart. Altogether, our studies support the hypothesis that ANF may function in humans as a volume- regulatory hormone whose plasma concentration is modulated by atrial pressure. The studies outlined in this proposal are designed to 1) determine the physiological, hormonal and volume stimuli which regulate human plasma ANF concentrations, 2) characterize the cardiovascular actions of ANF in normal subjects, and 3) elucidate the physiological regulation and cardiovascular actions of ANF in patients with essential hypertension. We plan to systematically manipulate atrial pressure, test a series of vasoactive agonists and manipulate plasma volume and osmolarity to determine the contribution of each of these stimuli to the regulation of plasma ANF concentration. Second, using bolus and sustained infusions of synthetic ANF we will determine its cardiovascular hemodynamic effect. Finally, we plan to test the hypothesis that the regulation of release and/or the cardiovascular actions of ANF are abnormal in human essential hypertension. The significance of these studies is that they will test the theory that ANF functions as a volume-regulatory hormone in human subjects, and that its cardiovascular actions are important to systemic and local vascular responsiveness. Secondly, these studies will determine whether the disordered volume regulation and altered vascular tone found in hypertension is due to abnormalities in the control of ANF release and/or in the actions of ANF.
心房利钠因子(ANF)是一种多肽激素

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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ALAN S HOLLISTER其他文献

ALAN S HOLLISTER的其他文献

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{{ truncateString('ALAN S HOLLISTER', 18)}}的其他基金

CARDIOVASCULAR PHARMACOLOGY OF ATRIAL NATRIURETIC FACTOR
心房钠尿因子的心血管药理学
  • 批准号:
    3352436
  • 财政年份:
    1987
  • 资助金额:
    $ 17.2万
  • 项目类别:
CARDIOVASCULAR PHARMACOLOGY OF ATRIAL NATRIURETIC FACTOR
心房钠尿因子的心血管药理学
  • 批准号:
    3352437
  • 财政年份:
    1987
  • 资助金额:
    $ 17.2万
  • 项目类别:
CARDIOVASCULAR PHARMACOLOGY OF ATRIAL NATRIURETIC FACTOR
心房钠尿因子的心血管药理学
  • 批准号:
    3352438
  • 财政年份:
    1987
  • 资助金额:
    $ 17.2万
  • 项目类别:
CARDIOVASCULAR PHARMACOLOGY OF ATRIAL NATRIURETIC FACTOR
心房钠尿因子的心血管药理学
  • 批准号:
    3352435
  • 财政年份:
    1987
  • 资助金额:
    $ 17.2万
  • 项目类别:
PLATELET A2-ADRENORECEPTOR REGULATION IN HYPERTENSION
高血压中血小板 A2-肾上腺素受体的调节
  • 批准号:
    3342523
  • 财政年份:
    1984
  • 资助金额:
    $ 17.2万
  • 项目类别:
PLATELET A2-ADRENORECEPTOR REGULATION IN HYPERTENSION
高血压中血小板 A2-肾上腺素受体的调节
  • 批准号:
    3342522
  • 财政年份:
    1984
  • 资助金额:
    $ 17.2万
  • 项目类别:
PLATELET ALPHA 2-ADRENORECEPTOR REGULATION IN HYPERTENSION
高血压中血小板α2-肾上腺素受体的调节
  • 批准号:
    3899420
  • 财政年份:
  • 资助金额:
    $ 17.2万
  • 项目类别:
CORE--LABORATORY CORE
核心--实验室核心
  • 批准号:
    3779729
  • 财政年份:
  • 资助金额:
    $ 17.2万
  • 项目类别:
PHARMACOKINETICS OF CONTROLLED RELEASE AND REGULAR FORMULATIONS OF AZT
AZT 控释和常规制剂的药代动力学
  • 批准号:
    3762491
  • 财政年份:
  • 资助金额:
    $ 17.2万
  • 项目类别:
INTERRELATION OF ANF SECRETAGOGUES AND PLASMA ANF IN HYPERTENSION
高血压中 ANF 分泌剂和血浆 ANF 的相互关系
  • 批准号:
    3740122
  • 财政年份:
  • 资助金额:
    $ 17.2万
  • 项目类别:

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