RIGHT VENTRICULAR FUNCTION

右心室功能

• 批准号: 3357445
• 负责人: WILLIAM P SANTAMORE
• 金额: $ 7.03万
• 依托单位: PRESBYTERIAN MEDICAL CENTER OF PHILA
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-15 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3357445
• 关键词: cardiac output; coronary disorder; dogs; epicardial mapping; heart contraction; heart septum; heart ventricle; intracardiac pressure; intracardiac volume; mathematical model

Right ventricular ejection has been attributed to a uniform reduction in the surface area of its free wall and to a reduction in the septal-to-free wall distance. This contraction pattern may lend itself to direct left ventricular assistance to right ventricular pump function. Even after total replacement of the right ventricular free wall with a Dacron patch or a Teflon cloth, the right ventricle still is able to develop pressure and outflow. This maintenance of right ventricular function may be due solely to septal contraction or conceivably, this maintenance of right ventricular function may represent a direct left ventricular assistance. This left ventricular assistance would occur directly not directly verified left ventricular assistance to right ventricular systolic function, nor have these studies determined the magnitude of this left ventricular assistance. Accordingly, this grant proposal will examine the following hypotheses: The left ventricle directly through the myocardium affects right ventricular systolic function; Under normal circumstances, at least half of right ventricular systolic function can be attributed to the left ventricle; Removing the pericardium will reduce left ventricular assistance; and, Regional ischemia will alter left ventricular assistance. The left ventricle can influence the right ventricle indirectly by altering output and directly through the myocardium. Accordingly, we will analyze transient changes in left and right ventricular pressures and dimensions following aortic and pulmonary vein constrictions to separate the direct (immediate) from the series (delayed) left ventricular effects on right ventricular pressures. Dimensional and pressure data will be recorded during aortic constriction (or release) and during pulmonary venous flow obstruction (or release). These measurements will be obtained with and without the pericardium. Additionally, these measurements will be obtained before and after creating ischemia restricted solely to the right ventricular free wall, the septum, or the left ventricular free wall. Computer analysis will separate the right ventricular systolic function. The analysis will also determine the magnitude of this left ventricular assistance. The new information obtained in this study will be of vital importance in understanding normal right ventricular function. Additionally, the information will help to explain the right ventricular response to ischemia and to pericardiotomy.

右心室射血归因于一种均匀的 其自由壁的表面积减小， 在隔膜到自由壁的距离上。 这种收缩模式可能 有助于将左心室直接辅助到右心室 心室泵功能 即使在完全更换 右心室游离壁用涤纶补片或聚四氟乙烯布， 右心室仍然能够产生压力和流出。 这种右心室功能的维持可能仅仅是由于 隔膜收缩，或者可以想象， 心室功能可以代表直接左心室收缩， 援助. 这种左心室辅助会直接发生在 未直接验证左心室对右心室的辅助 心室收缩功能，这些研究也没有确定 这个左心室辅助的大小。 因此，委员会认为， 这项拨款建议将审查以下假设： 左心室直接通过心肌影响右心室 心室收缩功能;在正常情况下，至少 右心室收缩功能的一半可归因于 左心室;移除心包将减少左心室 心室辅助;以及，局部缺血将改变左心室 心室辅助 左心室会影响右心室 通过改变输出间接地和直接地通过心室 心肌 因此，我们将分析左心室的瞬时变化， 和右心室压力和尺寸， 肺静脉收缩，以分离直接（立即） 从一系列（延迟）左心室对右心室的影响 心室压 尺寸和压力数据将 在主动脉收缩（或释放）期间和 肺静脉血流阻塞（或释放）。 这些测量 将在有和没有心包的情况下获得。 此外，本发明还 这些测量值将在创建之前和之后获得 缺血仅限于右心室游离壁， 室间隔或左心室游离壁。 计算机分析将 分离右心室收缩功能。 分析 也将决定左心室 援助. 本研究中获得的新信息将是 正确认识正常右心室 功能 此外，这些信息将有助于解释 右心室对缺血和心包切开术的反应。