VENTRICULAR INTERDEPENDENCE
心室相互依赖性
基本信息
- 批准号:3350655
- 负责人:
- 金额:$ 4.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-09-01 至 1990-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Classically, the heart is viewed-as consisting of two pumps in
series. with the out. put of one ventricle becoming the input to
the other ventricle. Thus, one ventricle could only influence the
other ventricle by changing its output, thereby eventually changing
the input to the other ventricle. However, the anatomical
association between the ventricles suggests that a direct
myocardial relationship exists. Changes in the volume or pressure
of one ventricle have been shown to affect the diastolic compliance
and shape of the contralateral ventricle. In isolated heart
preparations, changes in the left ventricular volume and free wall
integrity have been shown to alter right ventricular systolic
pressure. Recent experimental studies have shown changes in left
ventricular filling characteristics caused by acute changes in
right ventricular volume. Experimental and clinical data suggest
that ventricular interactions are also important in the
pathophysiology conditions. However, the previous studies have
been empirical with no direct, quantifiable measurement of
ventricular interdependence. Also, a theoretical analysis or
comprehensive view of ventricular interdependence is needed. To
better understand diastolic ventricular interdependence, this grant
proposal will develop techniques to quantify ventricular
interdependence and will develop a theoretical model to explain
the transfer of pressure and volume information between the
ventricles. Based upon the balance of forces across the septum.
four equations will be derived to explain the changes in
ventricular pressure or volume caused by changing the pressure or
volume of the contralateral ventricle. Using previously developed
experimental techniques, this grant proposal will validate the
theoretical analysis. More importantly, this grant proposal will
quantify ventricular interdependence both in vivo and in vitro in
the normal heart, will examine the effects of altered regional
compliance on ventricular interdependence, and will determine the
atrial contribution to ventricular interdependence. This grant
proposal will also quantify pericardial effects on ventricular
interdependence at normal and elevated levels of pericardial
pressure. The information obtained in this study will provide new
insight into the ventricular mechanics in normal and pathological
conditions; will provide a direct means to measure changes in
ventricular interdependence; and will improve the understanding of
the mechanisms of ventricular interdependence.
传统上,心脏被视为由两个泵组成,
系列.带着出去。 一个心室的输出成为
另一个心室 因此,一个心室只能影响
通过改变其他心室的输出,
输入到另一个心室 然而,解剖学
心室之间的联系表明,
存在心肌关系。 体积或压力的变化
已经显示影响舒张顺应性
和对侧脑室的形状 在孤立的心
准备、左心室容积和游离壁的变化
完整性已经显示出改变右心室收缩
压力 最近的实验研究表明,
急性改变引起的心室充盈特性
右心室容积 实验和临床数据表明
心室间的相互作用也很重要,
病理生理条件 然而,以前的研究
没有直接的,可量化的测量,
心室相互依赖 理论分析或
需要对心室相互依赖性的全面认识。 到
更好地了解舒张期心室的相互依赖性,
该提案将开发量化心室的技术,
相互依赖,并将开发一个理论模型来解释
压力和体积信息在
心室 基于隔膜上的力的平衡。
将推导出四个方程来解释
心室压力或容积变化引起的压力或容积变化,
对侧脑室的容积。 使用以前开发的
实验技术,这项赠款提案将验证
理论分析 更重要的是,这一计划将
在体内和体外定量心室相互依赖性,
正常的心脏,将检查改变的区域的影响,
心室相互依赖性的依从性,并将确定
心房对心室相互依赖性的贡献。 这笔赠款
该提案还将量化心包对心室的影响
心包水平正常和升高时的相互依赖性
压力 这项研究所获得的信息将提供新的
对正常和病理心室力学的认识
将提供一种直接的手段来衡量
心室相互依赖性;并将提高对
心室相互依赖的机制
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
WILLIAM P SANTAMORE其他文献
WILLIAM P SANTAMORE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('WILLIAM P SANTAMORE', 18)}}的其他基金
CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
冠状动脉狭窄、血管舒缩和血栓形成
- 批准号:
3350611 - 财政年份:1989
- 资助金额:
$ 4.66万 - 项目类别:
相似海外基金
Mindful Steps: A Web-Based Mind-Body Exercise Intervention to Promote Physical Activity in Chronic Cardiopulmonary Disease
正念步骤:基于网络的身心运动干预,促进慢性心肺疾病的体力活动
- 批准号:
10732824 - 财政年份:2023
- 资助金额:
$ 4.66万 - 项目类别:
Integrative Research Training Program in Pediatric Cardiopulmonary Disease
小儿心肺疾病综合研究培训计划
- 批准号:
10714157 - 财政年份:2023
- 资助金额:
$ 4.66万 - 项目类别:
Implementing Effective Smoking Cessation Pharmacotherapy for Hospitalized Smokers with Cardiopulmonary Disease
对患有心肺疾病的住院吸烟者实施有效的戒烟药物治疗
- 批准号:
10588125 - 财政年份:2022
- 资助金额:
$ 4.66万 - 项目类别:
Implementing Effective Smoking Cessation Pharmacotherapy for Hospitalized Smokers with Cardiopulmonary Disease
对患有心肺疾病的住院吸烟者实施有效的戒烟药物治疗
- 批准号:
10367000 - 财政年份:2022
- 资助金额:
$ 4.66万 - 项目类别:
Identifying the mechanisms for the effects of air pollution on cardiopulmonary disease in Beijing, China
确定中国北京空气污染对心肺疾病影响的机制
- 批准号:
NE/S006729/2 - 财政年份:2020
- 资助金额:
$ 4.66万 - 项目类别:
Research Grant
Identifying the mechanisms for the effects of air pollution on cardiopulmonary disease in Beijing, China
确定中国北京空气污染对心肺疾病影响的机制
- 批准号:
NE/S006729/1 - 财政年份:2019
- 资助金额:
$ 4.66万 - 项目类别:
Research Grant
The Impact of Bundled Payments for Cardiopulmonary Disease on High-Risk Populations
心肺疾病捆绑支付对高危人群的影响
- 批准号:
9917818 - 财政年份:2019
- 资助金额:
$ 4.66万 - 项目类别:
The Impact of Bundled Payments for Cardiopulmonary Disease on High-Risk Populations
心肺疾病捆绑支付对高危人群的影响
- 批准号:
10399472 - 财政年份:2019
- 资助金额:
$ 4.66万 - 项目类别:
Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology
北京空气污染对心肺疾病的影响:暴露科学、毒理基因组学和环境流行病学的综合研究
- 批准号:
NE/N007182/1 - 财政年份:2016
- 资助金额:
$ 4.66万 - 项目类别:
Research Grant
Effects of Air Pollution on Cardiopulmonary Disease in Urban and Peri-Urban Residents in Beijing
空气污染对北京市城区及城郊居民心肺疾病的影响
- 批准号:
NE/N007085/1 - 财政年份:2016
- 资助金额:
$ 4.66万 - 项目类别:
Research Grant