THERMODILUTION RIGHT VENTRICULAR EJECTION FRACTION

热稀释右心室射血分数

• 批准号: 2863525
• 负责人: WILLIAM P SANTAMORE
• 金额: $ 10万
• 依托单位: AMT, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-09 至 2000-05-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2863525
• 关键词: biomedical equipment development; catheterization; clinical biomedical equipment; computer simulation; heart ventricle; hemodynamics; swine; thermal blood flow measurement; thermodynamics

Availability of an accurate bedside method to determine right ventricular ejection fraction and size using a flow-directed balloon-tipped catheter would represent a major advance in the hemodynamic monitoring of patients. The thermal technique provides a convenient and inexpensive method for monitoring heart function at the bedside. A catheter (tube) is placed in the right heart through a vein. From this catheter, central venous pressure and pulmonary artery pressure can be measured. By injecting a cold salt solution (saline) and measuring the temperature changes in the pulmonary artery, the amount of blood pumped by the heart per minute can be calculated (cardiac output). This thermodilution technique is easy and reproducible, and has become a standard in clinical care. To this system, the measurement of the right ventricular ejection fraction was added. (RVEF) Precise measurement of ejection fraction has very important prognostic, diagnostic, and therapeutic advantages. However, experimental and clinical studies show that the thermodilution technique consistently underestimates RVEF and grossly overestimated RV end- diastolic volume. In this grant, we will develop a new thermodilution system, which will enable rapid, accurate assessment of right ventricular function. In Phased AMT Inc. will design and fabricate the catheters needed for the cardiac output and RV ejection fraction measurements. AMT and Temple University will collaborate on the computer simulation to test the basic concepts. The system to measure RVEF will be tested and validated in vivo by Dr. Santamore at Temple University. In Phase II, AMT Inc. will develop and build a self-contained electronic system to measure temperatures and calculate cardiac output, RV ejection fraction, RV end-diastolic and end-systolic volumes. PROPOSED COMMERCIAL APPLICATION: Not Available.

使用流动导向球囊尖端导管确定右心室射血分数和大小的准确床边方法的可用性将代表患者血流动力学监测的重大进展。热技术提供了一种方便和廉价的方法，在床边监测心脏功能。通过静脉将导管置入右心。通过该导管，可以测量中心静脉压和肺动脉压。通过注射冷盐溶液（生理盐水）并测量肺动脉中的温度变化，可以计算出心脏每分钟泵出的血液量（心输出量）。这种热稀释技术简单且可重复，已成为临床护理的标准。该系统增加了右心室射血分数的测量。精确测量射血分数具有非常重要的预后、诊断和治疗优势。然而，实验和临床研究表明，热稀释技术一贯低估RVEF和严重高估RV舒张末期容积。在这项资助中，我们将开发一种新的热稀释系统，这将使快速，准确的评估右心室功能。在阶段AMT公司。将设计和制造心输出量和RV射血分数测量所需的导管。AMT和坦普尔大学将合作进行计算机模拟，以测试基本概念。测量RVEF的系统将由坦普尔大学的Santamore博士进行体内测试和验证。在第二阶段，AMT Inc.将开发和构建一个独立的电子系统，用于测量温度和计算心输出量、RV射血分数、RV舒张末期和收缩末期容积。拟议的商业应用：不可用。