Implementation of a benchtop energy-dispersive X-ray diffraction computed tomography system for in vitro tissue characterisation

实施用于体外组织表征的台式能量色散 X 射线衍射计算机断层扫描系统

• 批准号: EP/I007911/1
• 负责人: Silvia Pani
• 金额: $ 12.8万
• 依托单位: University of Surrey
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI007911%2F1
• 关键词: Implementation; benchtop; energy; dispersive; ray

The project will develop novel geometries for Energy-Dispersive X-ray Diffraction Computed Tomography (EDXRDCT) for the characterisation of biological tissue, with specific focus on breast tissue. It will be carried out in collaboration with the School of Materials of the University of Manchester, the Cellular Pathology Department at Royal Surrey County Hospital, the National Coordinating Centre for Physics in Mammography and the Breast Screening Unit at Barts and The London NHS Trust and with the support of industrial collaborators (Morpho Detection, Inc. and South East Health Technology Alliance).X-ray diffraction allows identification of low-contrast lesions and their characterisation, including cancer identification and staging. Due to the intrinsic non-uniformity of biological tissue, characterisation of typical specimens based on X-ray diffraction requires the use of Computed Tomography (CT). However, work so far in the field of diffraction CT using polychromatic sources was limited to the first generation CT geometry, requiring overall acquisition times incompatible with clinical requirements.The present work will be based around the development and optimisation of two novel geometries that will reduce the acquisition times to a few minutes/slice. A system based on the combination of the two geometries could be used in the future for fast biopsy or characterisation of post-operatory specimens with a short enough timescale to guarantee minimum disruption to the clinical routine. This will allow fast and effective diagnosis of cancer, targeted treatment and reduction of unnecessary operations, thus contributing to an optimised use of resources in the Healthcare Service and to the general welfare of the population.The two geometries proposed will rely on a combination of cutting-edge technology and advanced data processing algorithms.Custom test objects will be designed and built to simulate the diffraction and geometrical properties of breast lesions. The two geometries proposed will be evaluated initially on these objects, and then, in the final stages of the project, on formalin-fixed breast tissue samples provided form the Cellular Pathology Department at Royal Surrey County Hospital. Tests on tissue samples will assess the repeatability of results from the same specimen using different geometries, and the repeatability of diffraction patterns from tissue regions from different specimens with the same histological properties.Results from these lab-based systems will be compared to those obtained using synchrotron radiation in collaborative experiments with the School of Materials at the University of Manchester, and to histological assessment using conventional methods.

该项目将为能量色散X射线衍射计算机断层扫描(EDXRDCT)开发新的几何结构，用于表征生物组织，特别是乳房组织。它将与曼彻斯特大学材料学院、皇家萨里郡医院的细胞病理科、国家乳房X光摄影物理协调中心和Barts的乳房筛查单位以及伦敦NHS信托基金合作进行，并得到行业合作者(Morpho Detect，Inc.和东南卫生技术联盟)的支持。X射线衍射可以识别低对比度病变及其特征，包括癌症识别和分期。由于生物组织固有的非均质性，基于X射线衍射的典型样品的表征需要使用计算机层析成像(CT)。然而，到目前为止，使用多色源的衍射CT领域的工作仅限于第一代CT几何结构，需要的总采集时间与临床要求不相容。目前的工作将基于两个新的几何结构的开发和优化，这将把采集时间减少到几分钟/切片。基于这两种几何结构组合的系统可以在未来用于快速活检或术后标本的鉴定，时间刻度足够短，以保证对临床常规的最小干扰。这将有助于快速有效地诊断癌症，进行有针对性的治疗，减少不必要的手术，从而促进医疗服务资源的最佳利用和公众的普遍福利。建议的两个几何形状将依赖于尖端技术和先进的数据处理算法的组合。将设计和建造定制的测试对象，以模拟乳房病变的衍射和几何特性。建议的两个几何形状将首先在这些对象上进行评估，然后在项目的最后阶段，在由皇家萨里县医院细胞病理科提供的福尔马林固定的乳房组织样本上进行评估。对组织样本的测试将评估同一样本使用不同几何形状的结果的重复性，以及来自具有相同组织特性的不同样本的组织区域的衍射图的重复性。这些基于实验室的系统的结果将与与曼彻斯特大学材料学院合作的实验中使用同步辐射获得的结果进行比较，并与使用传统方法的组织学评估进行比较。

项目成果

Breast tissue contrast-simulating materials using energy-dispersive X-ray diffraction.

使用能量色散 X 射线衍射模拟乳腺组织对比材料。

• DOI: 10.1016/j.apradiso.2012.03.027
• 发表时间: 2012
• 期刊: including data, instrumentation and methods for use in agriculture, industry and medicine
• 作者: Alkhateeb SM

Development and characterization of a laboratory based X-ray diffraction imaging system for material and tissue characterization.

用于材料和组织表征的实验室 X 射线衍射成像系统的开发和表征。

• DOI: 10.1016/j.apradiso.2012.03.023
• 发表时间: 2012
• 期刊: including data, instrumentation and methods for use in agriculture, industry and medicine
• 作者: Abdelkader MH

Development of geometries for fast X-ray diffraction computed tomography of soft tissue

软组织快速 X 射线衍射计算机断层扫描几何结构的开发

• 发表时间: 2012
• 作者: Abdelkader Mohamed Hassan Mohamed

Energy dispersive x-ray diffraction computed tomography of breast-mimicking test objects and breast tissue sample

仿乳腺测试对象和乳腺组织样本的能量色散X射线衍射计算机断层扫描

• 作者: Shyma Alkhateeb (Author)