SCHIZOPHRENIC COGNITION: A LONGITUDINAL STUDY

精神分裂症认知：一项纵向研究

• 批准号: 3374960
• 负责人: MARTIN HARROW
• 金额: $ 9.97万
• 依托单位: MICHAEL REESE HOSP & MED CTR (CHICAGO)
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-25 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3374960
• 关键词: behavior test; cognition disorders; delusions; human subject; longitudinal human study; mental disorder diagnosis; posthospitalization care; prognosis; psychobiology; psychological tests; psychometrics; psychosocial rehabilitation; schizophrenia; thinking; verbal behavior

The goal is to further our knowledge about schizophrenia and other major psychoses by a prospective longitudinal investigation, addressing the following major hypotheses about thought disorder, psychosis, negative symptoms, prognosis, functioning and adjustment over time in schizophrenia: Hypothesis 1: Positive thought disorder and/or psychosis are persisting features for most schizophrenics. The hypothesis runs counter to recent proposals that schizophrenia is a vulnerability to episodes, and is not a continuous disorder. Hypothesis 2: Schizophrenics with persisting positive thought disorder are nuclear schizophrenics with poor clinical courses and downhill life adjustment. Hypothesis 3: Negative symptoms are as predictive as positive symptoms of poor outcome in schizophrenia. Hypothesis 4: Psychosis persists or recurs over time in schizophrenia, but remits in other psychotic disorders. Hypothesis 5: Contrary to recent hypotheses, modern-day schizophrenics still have relatively poor outcomes. Schizophrenics are vulnerable to a sustained disorder and not just to intermittent episodes. The research involves a multifaceted prospective, longitudinal investigation of thought disorders, psychotic symptoms, negative symptoms, and major components of adjustment over time, using a battery of structured interviews, performance tests, thought disorder measures, and behavioral ratings. A large sample of early young, schizophrenic, schizoaffective, manic, and nonpsychotic patients are being assessed longitudinally. Patients have been evaluated at the acute phase, during partial recovery, and are being followed up at various phases during the posthospital period, for disordered thinking, psychotic symptoms, and negative symptoms. They also are being assessed for neurotic and affective symptoms, rehospitalization, and social and work adjustment. The data are used to evaluate a number of theories about thought disorder, psychosis, negative symptoms, prognostic factors, and to assess the long-term clinical course and level of functioning and adjustment in modern-day schizophrenia.

目的是进一步了解精神分裂症和其他主要疾病 精神病的前瞻性纵向调查，解决 根据关于思维障碍、精神病、负性 精神分裂症的症状、预后、功能和随时间的调整： 假设1：积极思维障碍和/或精神病持续存在 大多数精神分裂症患者的特征 这一假设与最近的 精神分裂症是一种脆弱的事件，而不是一个 连续无序 假设2：持续存在积极思维障碍的精神分裂症患者 临床病程差、生活每况愈下的核性精神分裂症患者 加强结构性改革 假设3：阴性症状与阳性症状一样具有预测性 精神分裂症预后差。 假设4：精神分裂症患者的精神病随着时间的推移持续存在或复发， 缓解其他精神障碍 假设5：与最近的假设相反，现代精神分裂症患者 仍然有相对较差的结果。 精神分裂症患者很容易受到 持续的紊乱而不仅仅是间歇性的发作。 该研究涉及多方面的前瞻性，纵向 调查思维障碍、精神病症状、阴性症状、 和主要组成部分的调整随着时间的推移，使用电池的结构化 访谈、表现测试、思维障碍测量和行为测试。 评级. 一个大样本的早期青年，精神分裂症，情感障碍，躁狂症， 对非精神病患者进行纵向评估。 患者 在急性期、部分恢复期进行了评价， 在产后期间的各个阶段进行随访， 思维障碍精神病症状和阴性症状 他们还 正在接受神经症和情感症状的评估，再次住院， 以及社会和工作调整。 这些数据被用来评估一些 思维障碍理论，精神病，阴性症状，预后 因素，并评估长期的临床过程和水平， 现代精神分裂症的功能和调整。