BRAIN MONOAMINES AND CONDITIONED BEHAVIOR

这项拟议研究的长期目标是了解 中枢神经系统神经递质系统在高血压病中的调节作用 精神药物在维持行为方面的作用。我们 将重点放在多巴胺、去甲肾上腺素、5-羟色胺和伽马氨基上 丁酸及其与操作者行为的关系。进食， 饮酒和运动也将被研究，因为它们很重要。 操作型行为的组成部分。神经递质的作用将是 被药物和/或神经毒素修饰的。将使用以下工具测量行为 面向计算机的技术。有两个大致定义的焦点 当前应用程序。首先，我们将尝试确定以下方面的变化 神经递质系统，当操纵性行为被 抗抑郁药物的管理。这项研究的目标是 阐明导致中枢神经系统神经化学变化的原因 行为的改变，并可能参与了精神分裂症的病理生理 抑郁症。第二，我们将尝试识别神经化学物质 中枢神经系统中的机制 药物-行为-环境相互作用进一步了解相关 药物和环境在行为改变中的作用。

The long-range aim of the proposed research is to understand the role central nervous system neurotransmitter systems play in the mediation of the actions of psychotropic drugs and in the maintenance of behavior. We will focus on dopamine, norepinephrine, 5-hydroxytryptamine and gamma amino butyric acid, and their relationship to operant behavior. Feeding, drinking and locomotion will also be studied since they are important components of operant behavior. The actions of neurotransmitters will be modified by drugs and/or neurotoxins. Behavior will be measured using computer-oriented techniques. There are two broadly defined foci of the current application. First, we will attempt to identify changes in neurotransmitter systems that occur when operant behavior is modified by administration of antidepressant drugs. The goal of this research is to elucidate changes in central nervous system neurochemistry which lead to changes in behavior and which may be involved in the pathophysiology of depression. Second, we will attempt to identify the neurochemical mechanisms in the central nervous system that account for drug-behavior-environment interactions to further understand the relative roles of drugs and the environment in modifications of behavior.