BRAIN MONOAMINES AND CONDITIONED BEHAVIOR

这项研究的最终目标是了解 脑神经递质系统在 精神药物和维持行为。 的 研究将集中在多巴胺的行为参与， 去甲肾上腺素和5-羟色胺。 行为将被衡量 使用计算机控制的实时数据应用系统。 的 研究将采用两种密切相关的平行方法。 在 第一种方法，一种敏感而具体的操作性行为， 将使用检测具有抗抑郁作用的药物的屏幕 以确定儿茶酚胺能和肾上腺素能成分， 抗抑郁药物的作用。 此外，还将进行研究， 确定去甲肾上腺素多巴胺和5-羟色胺 系统相互作用产生抗抑郁作用。 的目标 这项研究是为了阐明神经化学变化， 介导抗抑郁药物对操作行为的影响。 知识 这些神经化学变化可以提供深入了解 抑郁症的病理生理学 对于第二种方法，研究 将确定神经化学机制，介导 药物、行为和环境之间的相互作用。 药物 对行为的影响不仅取决于具体的药物和剂量 但也取决于药物的环境 是管理和持续的行为。 因此，我们认为， 神经化学变化将被测量为 系统地改变环境和行为参数。 环境和行为参数的知识是独立的 改变大脑化学的变量会提供额外的 深入了解精神疾病的病理生理学

The ultimate goal of this proposed research is to understand the role of brain neurotransmitter systems in the actions of psychotropic drugs and in the maintenance of behavior. The research will focus on the behavioral involvement of dopamine, norepinephrine, and 5-hydroxytryptamine. Behavior will be measured using a computer-controlled real-time data application system. The research will employ two closely related parallel approaches. In the first approach, a sensitive and specific operant behavioral screen that detects drugs with antidepressant action will be used to determine the catecholaminergic and serotonergic components of antidepressant drugs effects. Also, studies will be done to determine whether norepinephrine, dopamine and 5-hydroxytryptamine systems interact to produce antidepressant effects. The goal of this research is to elucidate the neurochemical changes that mediate antidepressant drug effects on operant behavior. Knowledge of these neurochemical changes could provide insight into the pathophysiology of depression. For the second approach, studies will be done to determine the neurochemical mechanisms that mediate interactions between drugs, behavior and the environment. Drug effects on behavior depend not only on the specific drug and dose of the drug, but also depend on the environment in which the drug is administered and on the ongoing behavior. Therefore, neurochemical change will be measured as a function of systematically varied environmental and behavioral parameters. Knowledge of environmental and behavioral parameters as independent variables that alter brain chemistry would provide additional insight into the pathophysiology of mental illness.