MODELS FOR TREATING HIGH BLOOD CHOLESTEROL

治疗高胆固醇的模型

• 批准号: 3362947
• 负责人: ARLENE W CAGGIULA
• 金额: $ 30.11万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-30 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3362947
• 关键词: blood lipoprotein; cardiovascular disorder education; cardiovascular disorder epidemiology; chemotherapy; cholesterol; diet; diet therapy; disease /disorder model; eating; health care cost /financing; health care model; human subject; medical education; model design /development; physicians; reducing diet; therapy compliance

In order to fully and effectively implement the guidelines of the National Cholesterol Education Program's Adult Treatment Guidelines, models for implementation within physicians office practices must be designed, tested, and evaluated for cost/effectiveness. This study has been designed to compare the efficacy of three implementation models in two phases: Model 1, Basic office based implementation (Phase 1); Model 2, Office assisted implementation and Model 3, Basic office based implementation plus an inclusive nutritional/ behavioral intervention offered through a community nutrition center. Practices will be randomized after Phase 1 into two conditions in order to test Models 2 and 3. Model 1 will serve as a control group for the other two models and will also provide information on patient eligibility, recruitment patterns and accrual rates. Cholesterol response after 3 months of intervention will be the primary end-point although patients will be followed in Phase 2 for up to two years in order to determine long-term cholesterol response, patterns of drug therapy as well as effectiveness of drug therapy, and drop out rates. The cost/effectiveness of each of the models will be calculated. Twenty physician practices will be recruited from a group of thirty practices already identified in the greater Pittsburgh area. Each practice will accrue at least 40 patients who will be treated according to the NCEP, ATP guidelines. The results of this study will provide important information as to the number of patients who will be willing to enter therapy, the number who will successfully lower their blood cholesterol levels by dietary approaches alone, and the number who will require drug therapy and the response to this therapy. Finally, we will be able to determine the cost/effectiveness of each approach.

为全面有效贯彻落实《意见》 国家胆固醇教育计划的成人治疗指南， 在医生办公室实践中实施的模型必须是 设计、测试和评估成本/效益。 本研究旨在比较三种方法的功效 分两个阶段的实施模式：模式1，基于基本办公室 实施（第一阶段）；模式2、Office协助实施和 模型 3，基于基本办公室的实施加上包容性的实施 通过社区提供的营养/行为干预 营养中心。第一阶段后练习将随机分为两个 条件以测试模型 2 和 3。模型 1 将作为 其他两个模型的对照组也将提供信息 患者资格、招募模式和应计率。 干预 3 个月后的胆固醇反应将是主要的 终点，尽管患者将在第 2 阶段进行最多两次随访 多年以确定长期胆固醇反应，模式 药物治疗以及药物治疗的有效性，并退出 费率。将计算每个模型的成本/有效性。 将从三十人的小组中招募二十名执业医师 大匹兹堡地区已经确定了这种做法。每个 实践将积累至少 40 名患者，他们将根据 NCEP、ATP 指南。这项研究的结果将提供 有关愿意的患者数量的重要信息 进入治疗，成功降低血液的人数 仅通过饮食方法来确定胆固醇水平，以及有多少人会 需要药物治疗以及对此治疗的反应。最后，我们将 能够确定每种方法的成本/有效性。