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MODELS FOR TREATING HIGH BLOOD CHOLESTEROL

治疗高胆固醇的模型

基本信息

批准号：
2221351
负责人：
ARLENE W CAGGIULA
金额：
$ 24.31万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-09-30 至 1995-07-31
项目状态：
已结题

项目摘要

In order to fully and effectively implement the guidelines of the National Cholesterol Education Program's Adult Treatment Guidelines, models for implementation within physicians office practices must be designed, tested, and evaluated for cost/effectiveness. This study has been designed to compare the efficacy of three implementation models in two phases: Model 1, Basic office based implementation (Phase 1); Model 2, Office assisted implementation and Model 3, Basic office based implementation plus an inclusive nutritional/ behavioral intervention offered through a community nutrition center. Practices will be randomized after Phase 1 into two conditions in order to test Models 2 and 3. Model 1 will serve as a control group for the other two models and will also provide information on patient eligibility, recruitment patterns and accrual rates. Cholesterol response after 3 months of intervention will be the primary end-point although patients will be followed in Phase 2 for up to two years in order to determine long-term cholesterol response, patterns of drug therapy as well as effectiveness of drug therapy, and drop out rates. The cost/effectiveness of each of the models will be calculated. Twenty physician practices will be recruited from a group of thirty practices already identified in the greater Pittsburgh area. Each practice will accrue at least 40 patients who will be treated according to the NCEP, ATP guidelines. The results of this study will provide important information as to the number of patients who will be willing to enter therapy, the number who will successfully lower their blood cholesterol levels by dietary approaches alone, and the number who will require drug therapy and the response to this therapy. Finally, we will be able to determine the cost/effectiveness of each approach.

为了充分有效地执行《联合国宪章》的指导方针，国家胆固醇教育计划的成人治疗指南，在医生办公室实践中实施的模型必须设计、测试和评估成本/效益。本研究旨在比较三种药物的疗效。实施模式分为两个阶段：模式1，基于基本办公室模式2，办事处协助执行，模式3，基于办公室的基本实施加上包容性通过社区提供的营养/行为干预营养中心。在第1阶段后，实践将随机分为两个阶段为了测试模型2和模型3。Model 1将作为对照组的其他两种模式，并将提供信息患者资格、招募模式和累积率。干预3个月后的胆固醇反应将是主要的尽管患者将在2期研究中接受最多2个为了确定长期胆固醇反应，药物治疗以及药物治疗的有效性， rates.将计算每种模式的成本/效益。将从30名医生中招募20名在大匹兹堡地区已经确定的做法。每个实践将累积至少40名患者，他们将根据 NCEP和ATP的指导方针这项研究的结果将提供关于愿意接受治疗的患者数量的重要信息进入治疗，成功降低他们的血液胆固醇水平仅通过饮食方法，需要药物治疗和对这种治疗的反应。最后我们将能够确定每种方法的成本/效益。