NONINVASIVE MYOCARDIAL MOTION ANALYSIS WITH MRI

详细了解心肌动力学是理解 正常的心脏生理和运动异常 与许多心脏病相关。 我们学到的很多东西 关于心肌动力学， 可以跟踪单个心肌节段的技术。 电流 非侵入性技术还不能准确地重现这些 数据，部分原因是它们不遵循单独的段， 把整体运动和室壁增厚混淆了虽然其他MRI方法提供 承诺通过使用 磁心肌标记，他们有有限的空间和时间 分辨率，无法检查整个心动周期，并需要 考试时间长。 我们建议克服这些限制 通过采购的开发、评估和验证， 基于心肌相位对比MRI图像的分析方法 速度 这种新颖的方法允许任意定位的区域，如 小到几立方毫米，可以在任何地方回顾性地选择， 心脏，并在整个心动周期中跟踪d-D。 此外，本发明还 可以测量瞬时区域应变、剪切、扭转和扭转 而不需要复杂的模式识别算法。 该方法将通过使用体模进行全面评价， 通过与动物和患者的荧光镜测量比较， 在手术时植入了不透射线标记。 手术后的心肌动力学将在患者中进行研究， 正常和移植心肌力学 将对人类心脏进行评估。 一旦验证，该技术应 使心肌运动的非侵入性研究， 分辨率和范围，并可提供给MRI中心 在全世界都有。 所提出的相衬MRI技术可以 对正常心肌的理解有重大影响， 功能，在评价患者的心脏病理， 治疗的选择、影响和时机。

Detailed knowledge of myocardial dynamics is central to understanding normal cardiac physiology and motion abnormalities are closely correlated with many cardiac pathologies. Much of what has been learned concerning myocardial dynamics has been though the use of invasive techniques which can track individual myocardial segments. Current noninvasive techniques have not been able to exactly reproduce these data, in part because they do not follow individual segments and may confuse bulk motion with wall thickening. While other MRI methods offer promise to partially address these limitations through the use of magnetic myocardial tagging, they have limited spatial and temporal resolution, are unable to examine the entire cardiac cycle, and require long examination times. We propose to overcome these limitations through the development, evaluation and validation of acquisition and analysis methods based on phase contrast MRI maps of myocardial velocity. This novel approach allows arbitrarily positioned regions, as small as a few cubic mm, to be selected retrospectively anywhere in the heart and followed in d-D throughout the entire cardiac cycle. Further, instantaneous regional strain, shear, torsion and twist can be measured directly without requiring sophisticated pattern recognition algorithms. The method will be thoroughly evaluated through the use of phantoms and by comparison with fluoroscopic measurements in animals and patients who have had radiopaque markers implanted at the time of surgery. Myocardial dynamics after surgery will be studied in patients and animals, and the myocardial mechanics of the normal and transplanted human heart will be evaluated. Once validated, this technique should allow the noninvasive study of myocardial motion with unprecedented resolution and scope, and can be made available to MRI centers throughout the world. The proposed phase contrast MRI techniques could have a significant impact in the understanding of normal myocardial function, in the evaluation of cardiac pathologies in patients, and in the choice, impact and timing of therapy.