Inverse Geometry CT for Dose-efficient Volumetric Imaging

描述（申请人提供）：通知编号：（NOT-OD-09-058）通知标题：该项目的长期目标是开发一种全新的计算机断层扫描（CT）系统设计，该系统有望提供上级剂量效率和降低的患者剂量，提高空间和时间分辨率，和无伪影的大容量覆盖。与传统CT系统使用的单个X射线源相比，基本概念，逆几何CT（IGCT），采用X射线源阵列。该方法承诺体积覆盖在一个单一的快速扫描没有“锥束伪影”，替代技术面临的。此外，对于可比的图像质量，该方法可以显著降低患者剂量。R 01资助的主要目标是开发有史以来第一个基于机架的IGCT系统。由于资源有限，目前的计划是第一次实施时采用一个由8个源组成的源模块。此竞争性修订应用程序的目的是构建3个额外的源模块，使总数达到32个源。此次修订将为建筑材料和劳动力提供资金，并将额外的资源整合到已经设计用于容纳4个模块的房屋中。将利用母基金提供的资源对改进后的源阵列进行详细的评估和测试。这种范围的增强将使我们能够研究虚拟领结，并在更接近最终临床设置的条件下测试IGCT的性能。 公共卫生相关性：逆几何CT能够进行器官旋转成像，而不会出现锥束伪影，具有提高空间和时间分辨率的潜力，并提供了一种方法，可显著降低获得所需临床信息所需的辐射暴露。从历史上看，CT性能的改进总是带来重要的新应用，最大限度地减少CT扫描的辐射剂量是一个显著的好处，特别是在儿童和其他电离辐射影响风险较高的群体中。这一竞争性修订将加速这一有前途的技术的开发和评估。

DESCRIPTION (provided by applicant): Notice Number: (NOT-OD-09-058) Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications Project Summary The long term goal of this project is to develop a radically new Computed Tomography (CT) system design that promises to provide superior dose-efficiency and decreased patient dose, improved spatial and temporal resolution, and artifact-free wide volume coverage in a single fast rotation. The underlying concept, Inverse Geometry CT (IGCT), employs an array of x-ray sources in contrast to the single x-ray source used by conventional CT systems. The approach promises volumetric coverage in a single fast scan without "cone beam artifacts" that alternative techniques face. In addition, for comparable image quality, the approach could lead to significant reductions in patient dose. The main goal of the parent R01 grant is to develop the first ever, gantry-based IGCT system. Because of resource limitations, the current plan is for this first implementation to have one source module comprised of 8 sources. The aim of this competitive revision application is to build 3 additional source modules, bringing the total to 32 sources. The revision will fund the materials and labor for construction and integration of the additional sources into a housing that was already designed to accommodate 4 modules. The detailed evaluation and testing of the improved source array will be conducted using resources from the parent grant. This scope enhancement will allow us to study the virtual bowtie and to test the performance of IGCT under conditions closer to those of eventual clinical settings. PUBLIC HEALTH RELEVANCE: Inverse Geometry CT is capable of organ-in-rotation imaging without cone-beam artifacts, has the potential for improved spatial and temporal resolution, and offers an approach to significantly reduce the radiation exposure needed to obtain the required clinical information. Historically, improvements in CT performance have always led to important new applications, and minimizing the radiation dose of CT scanning is a significant benefit, especially in children and other groups at higher risk from the effects of ionizing radiation. This competitive revision will accelerate the development and evaluation of this promising technology.