Cell Control in a Petri Dish (CCPD) Collaborative Network

培养皿中的细胞控制 (CCPD) 协作网络

• 批准号: EP/I037237/1
• 负责人: Weng Chan
• 金额: $ 16.04万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI037237%2F1
• 关键词: Cell; Control; Petri; Dish; CCPD

The human body is made up of tissues and organs that are themselves made up of smaller components known as cells. Changes in these cell populations influence how they function and can result in the tissue becoming diseased or affecting how well it repairs and regenerates. We can isolate these cells from the body, grow them in a Petri dish in the laboratory and use them to study disease and the regenerative process. In addition, we can use them to screen new drugs to see how they are effective they are and confirm that they do not damage other tissues (such as the liver). Over the years, chemists have been designing and making small molecules primarily as new drugs to treat diseased cells but recent research has suggested that we can use these molecules in the laboratory to make normal cells diseased or to influence cell populations involved in the repair process known as stem cells. By doing this, we will be able to understand the cell in much greater detail and this knowledge will undoubtedly lead to better treatments in the future. To do this though, we need cell biologists and chemists, who are often based in separate departments and buildings and may not even know each other, to work more closely together. The aim of this network is to bring these scientists together, along with people based in industry, and create an environment for discussion and to encourage them to embark on this new research area to better understand how small molecules can influence cell function.

人体是由组织和器官组成的，而这些组织和器官本身又是由称为细胞的较小成分组成的。这些细胞群的变化会影响它们的功能，并可能导致组织患病或影响其修复和再生的程度。我们可以将这些细胞从身体中分离出来，在实验室的培养皿中培养它们，并用它们来研究疾病和再生过程。此外，我们可以用它们来筛选新药，看看它们是如何有效的，并确认它们不会损害其他组织（如肝脏）。多年来，化学家一直在设计和制造小分子，主要是作为治疗病变细胞的新药，但最近的研究表明，我们可以在实验室中使用这些分子使正常细胞病变，或影响参与修复过程的细胞群，即干细胞。通过这样做，我们将能够更详细地了解细胞，这些知识无疑将在未来带来更好的治疗方法。然而，要做到这一点，我们需要细胞生物学家和化学家更密切地合作，他们通常位于不同的部门和建筑物，甚至可能彼此不认识。该网络的目的是将这些科学家与工业界人士沿着聚集在一起，创造一个讨论的环境，并鼓励他们开始这一新的研究领域，以更好地了解小分子如何影响细胞功能。