NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA

这项工作的主要目标是定义神经生理学异常。 从而为更理性的方法奠定了基础 去接受治疗。第一组研究将考察 我们的三次重复的听觉地形图不对称的发现 精神分裂症患者的P300事件相关电位 “左颞叶特征”(LTF)，包括在 最大限度地区分精神分裂症患者和正常人的T3。它的存在 在一个更大的未用药的精神分裂症组中将被确定。一个 纵向研究将探讨LTF的状态-特质性质 精神分裂症及其与临床状态变化的协变性， 包括阳性症状。将检查其诊断特异性 患有严重情绪障碍的精神病患者的对照组 功能(双极和单极)。 本申请还提出了新的ERP和相关的注意措施 精神分裂症患者的左半球和注意病理学都将 与P300 LTF相辅相成并形成对比。VISUAL N400和ERP 与语义不一致相关联，将被用作可能的收敛 测量，因为N400和P300都可能有颞叶来源和两者 可能与阳性症状有关。N400将在#年进行研究 精神分裂症患者与正常对照组和双相情感障碍对照组 具有精神病特征的单相情绪障碍。现进一步建议 发展“躁狂型”和“精神分裂症型”异常句 将具有特定于每个诊断组的N400效果的完成， 并确定个体思维障碍的关系 患者(语音完形概率)对N400事件相关电位异常的影响。AS 与此形成对比的是，该应用程序建议调查 报道的P200异常及其与阴性症状的相关性 将在未用药的精神分裂症受试者身上复制。一个计算机化的 使用退化刺激匹配初始刺激的视觉连续操作任务 患者和正常人的表现将决定P300 LTF是否 与精神分裂症在持续性注意力上的缺陷有关。视觉P300 将检查CPT的目标刺激的事件相关电位，以确定 幅度和地形异常随地震波速的下降而变化 性能。最后，为了与我们的听觉任务进行对比，并作为一种 大脑半球病理的互补和对比测量，“波斯纳 视觉注意测试的“范式”将在非药物治疗中使用 精神分裂症患者和正常人来确定是否有右脑 初步数据显示，存在视觉注意力缺陷。方法论 建议研究的特点包括28个电极的头皮记录， 年龄匹配的正常对照组、未用药患者(除 纵向研究)，并使用多变量统计进行假设 测试。

The broad goal of this work is to define neurophysiological abnormalities in schizophrenia, and thus to lay a foundation for a more rational approach to treatment. A first group of studies will examine the characteristics of our thrice-replicated findings of a topographic asymmetry of the auditory P300 event-related potential (ERP) in schizophrenics, referred to as the "left temporal feature" (LTF) and consisting of an amplitude reduction at T3 that maximally differentiates schizophrenics from normals. Its presence in a larger unmedicated schizophrenic group will be determined. A longitudinal study will investigate the state-trait nature of the LTF in schizophrenics and its covariation with changes in clinical status, including positive symptoms. Its diagnostic specificity will be examined in contrast groups of patients with major mood disorders with psychotic features (bipolar and unipolar). This application also proposes new ERP and attentional measures bearing on left hemisphere and attentional pathology in schizophrenia that will both complement and contrast with the P300 LTF. The visual N400, and ERP associated with semantic incongruity, will be used as a possible convergent measure, since both N400 and P300 may have temporal lobe sources and both may be associated with positive symptoms. The N400 will be studied in schizophrenics and contrast groups of normal controls and of bipolar and unipolar mood disorders with psychotic features. It is further proposed to develop "manic-specific" and "schizophrenic-specific" anomalous sentence completions that will have N400 effects specific to each diagnostic group, and to determine the relationship of thought disorder in individual patients (cloze probabilities of speech) to the N400 ERP abnormalities. As a contrasting measure, the application proposes to investigate whether the P200 abnormalities and their correlations with negative symptoms reported by us will replicate in unmedicated schizophrenic subjects. A computerized visual continuous performance task using degraded stimuli to match initial performance of patients and normals will determine if the P300 LTF is related to a schizophrenic deficit in sustained attention. Visual P300 ERPs to the target stimuli of the CPT will be examined to determine if amplitude and topographic abnormalities covary with a decline in performance. Finally, to contrast with our auditory tasks, and as a complementary and contrasting measure of hemispheric pathology, the "Posner paradigm" of visual attention testing will be utilized in unmedicated schizophrenics and normals to determine if there is a right hemisphere visual attention deficit, as preliminary data suggest. Methodological features of the studies proposed include 28-electrode scalp recordings, age-matched normal control groups, unmedicated patients (except for the longitudinal study), and the use of multivariate statistics for hypothesis testing.